全部文献期刊学位论文会议报纸专利标准年鉴图书|学者科研项目
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作者:Xiang Ding , Qiukui Hao , Ming Yang ...
来源:[J].BMC Medical Genetics(IF 2.536), 2017, Vol.18 (1)Springer
摘要:Recent evidence indicates that ataxia telangiectasia mutated (ATM) is a cytoplasmic protein that involves in insulin signaling pathways. When ATM gene is mutated, this event appears to contribute to the development of insulin resistance and type 2 diabetes mellitus (T2DM). Up to ...
作者:Zhipeng Yan , Xiang Tong , Yao Ma ...
来源:[J].BMC Pulmonary Medicine(IF 2.76), 2017, Vol.17 (1)Springer
摘要:... The ataxia telangiectasia mutated (ATM) gene plays an important role in the DNA DSB repair pathway. DNA damage is a major cytotoxic effect that can be caused by radiation, and the ability to repair DNA after damage varies among different tissues. Impaired DNA repair pathways ...
作者:Hao Luo , Jianyou Shi , Lufei Lu ...
来源:[J].Medicinal Chemistry Research(IF 1.612), 2014, Vol.23 (2), pp.747-758Springer
摘要:Abstract(#br)The ataxia telangiectasia mutated and Rad3 related (ATR) protein kinase is one of the apical regulators in the DNA damaging response signaling pathways. Inhibition of ATR kinase may greatly potentiates the cyto-toxicity by DNA damaging agents to the tumor cells w...
作者:Ji Hoon Yu , Soon Ok Cho , Joo Weon Lim ...
来源:[J].International Journal of Biochemistry and Cell Biology(IF 4.152), 2015, Vol.60, pp.147-156Elsevier
摘要:Abstract(#br)Ataxia telangiectasia (AT) is caused by mutational inactivation of the ataxia telangiectasia mutated ( Atm ) gene, which is involved in DNA repair. Increased oxidative stress has been shown in human AT cells and neuronal tissues of Atm -deficient mice. Heme oxygena...
作者:Roger W.L. Godschalk , Kimberly Vanhees , Lou Maas ...
来源:[J].Reproductive Toxicology(IF 3.141), 2016, Vol.63, pp.169-173Elsevier
摘要:... G6PDH is regulated by the Ataxia Telangiectasia Mutated (Atm) protein. Therefore, we studied the redox status and DNA damage in testes and sperm of mice that carried a deletion in Atm . The redox status in heterozygote mice, reflected by glutathione levels and antioxidant cap...
作者:Rebecca J. Smith , Matthew S. Savoian , Lauren E. Weber ...
来源:[J].BMC Molecular Biology(IF 2.796), 2016, Vol.17 (1)Springer
摘要:Abstract(#br) Background(#br)Ataxia telangiectasia mutated (ATM) and TRRAP proteins belong to the phosphatidylinositol 3-kinase-related kinase family and are involved in DNA damage repair and chromatin remodeling. ATM is a checkpoint kinase that is recruited to sites of DNA dou...
作者:Shun Fujimaki , Yasunobu Matsuda , Toshifumi Wakai ...
来源:[J].Cancer Letters(IF 4.258), 2012, Vol.319 (1), pp.98-108Elsevier
摘要:... Here, we show that blockade of ataxia telangiectasia mutated (ATM) improves the antitumor effects of sorafenib. When hepatoma cell lines HepG2 and PLC/PRF/5 were treated with sorafenib plus ATM small inhibitory RNAs, ATM inhibitor KU55933 or caffeine, Akt signaling was suppre...
作者:S. V. Khoronenkova
来源:[J].Biochemistry (Moscow)(IF 1.149), 2016, Vol.81 (13), pp.1669-1675Springer
摘要:... Noncanonical ATM activation may be important for the pathology of the multisystemic disease Ataxia Telangiectasia.
作者:Akshar Y. Patel , Todd M. McDonald , Larry D. Spears ...
来源:[J].Biochemical and Biophysical Research Communications(IF 2.406), 2011, Vol.405 (4), pp.599-603Elsevier
摘要:Abstract(#br)Cells lacking ataxia telangiectasia mutated (ATM) have impaired mitochondrial function. Furthermore, mammalian cells lacking ATM have increased levels of reactive oxygen species (ROS) as well as mitochondrial DNA (mtDNA) deletions in the region encoding for cytoc...
作者:Saranya Vilvanathan , Umamaheswaran Gurusamy , V Mukta ...
来源:[J].Indian Journal of Endocrinology and Metabolism, 2014, Vol.18 (6), pp.850-854DOAJ
摘要:Allele and genotype frequency of a genetic variant in ATM gene affecting glycemic response to metformin in South Indian population . Context: The novel polymorphism in ATM gene (rs11212617), which is implicated to have association with metformin response, exhibits inter-ethnic va...

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