全部文献期刊会议图书|学者科研项目
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作者:K.V.S. Mani Chandrika , Sahida Sharma
来源:[J].Bioorganic & Medicinal Chemistry(IF 2.903), 2020, Vol.28 (7)
摘要:... Side by side, the appearance of drug resistance to the presently available antifungal therapeutics is on a rapid rise. It has become a top priority for the academia and pharmaceutical industries to develop new antifungal agents able to combat this resistance, and at the same ...
作者:Heun Choi , Jung Ho Kim , Hye Seong ...
来源:[J].International Journal of Infectious Diseases(IF 2.357), 2019, Vol.83, pp.49-55
摘要:Abstract(#br)Objectives(#br)In 2014, South Korea expanded its national health insurance coverage to include newer antifungal agents, such as echinocandins. This study aimed to investigate the effects of policy change on the prescription patterns of antifungals, medical costs ...
作者:Kevin Watt , Daniel K. Benjamin , Michael Cohen-Wolkowiez
来源:[J].Early Human Development(IF 2.02), 2011, Vol.87, pp.S61-S65
摘要:... The first antifungal agents such as amphotericin B and fluconazole offered effective treatment, but their use was often limited by toxicity and resistance. Numerous new antifungal agents have since been developed and appear to be as effective. Most dosing and safety trials ha...
作者:Jason M. Cota , Alireza FakhriRavari , Matthew P. Rowan ...
来源:[J].Clinical Therapeutics(IF 2.23), 2016, Vol.38 (9), pp.2016-2031
摘要:... However, anti-infective dose selection is difficult because of the highly abnormal physiologic features of burn patients, which can greatly affect the pharmacokinetic (PK) disposition of these agents. We review published PK data from burn patients and offer evidence-based d...
作者:Xiaoyun Chai , Jun Zhang , Yongbing Cao ...
来源:[J].European Journal of Medicinal Chemistry(IF 3.499), 2011, Vol.46 (7), pp.3167-3176
摘要:Abstract(#br)In order to meet the urgent need for novel antifungal agents with improved activity and broader spectrum, a series of 1-(1 H -1,2,4-triazol-1-yl)-2-(2,4-difluorophenyl)-3-[(4-substituted trifluoromethyl phenyl)-piperazin-1-yl]-propan-2-ols were designed, synthesize...
作者:Stéphanie Vandekerckhove , Hai Giang Tran , Tom Desmet ...
来源:[J].Bioorganic & Medicinal Chemistry Letters(IF 2.338), 2013, Vol.23 (16), pp.4641-4643
摘要:Abstract(#br)Antifungal assessment of eighteen 5-, 6- and 8-(4-aminobutyloxy)quinolines revealed a significant susceptibility of the tested fungi and yeast strains ( Candida albicans , Rhodotorula bogoriensis , Aspergillus flavus and Fusarium solani ) toward different halo-substi...
作者:Tatiana B. Spader , Tarcieli P. Venturini , Luana Rossato ...
来源:[J].Revista Iberoamericana de Micologia(IF 1.312), 2013, Vol.30 (3), pp.200-204
摘要:Abstract(#br)Background(#br)Infections caused by Fusarium are difficult to treat because these fungi show in vitro and in vivo resistance to practically all the antifungal agents available, which explains the high mortality rates. An attempt to overcome fungal resistance is the...
作者:Qinggang Ji , Qiao Deng , Bing Li ...
来源:[J].European Journal of Medicinal Chemistry(IF 3.499), 2019, Vol.180, pp.204-212
摘要:Abstract(#br)A series of 5-(4-substituted piperazin-1-yl)quinolin-2(1 H )-one derivatives (4a-4w) has been designed as chitin synthase inhibitors and antifungal agents. The designed compounds were obtained by an environmentally benign route in four steps starting from 5-amino-...
作者:Muthu K Kathiravan , Amol B Salake , Aparna S Chothe ...
来源:[J].Bioorganic & Medicinal Chemistry(IF 2.903), 2012, Vol.20 (19), pp.5678-5698
摘要:Abstract(#br)In recent years their has been an increased use of antifungal agents and has resulted in the development of resistance to drugs. Currently, use of standard antifungal therapies can be limited because of toxicity, low efficacy rates. Different types of mechanisms cont...
作者:Vibha C.A. Desai , Teresa M. Cavanaugh , Christina M.L. Kelton ...
来源:[J].Clinical Therapeutics(IF 2.23), 2012, Vol.34 (10), pp.2118-2131.e1
摘要:...(#br)Objective(#br)To provide a historical perspective on a dynamic market with expensive medications, this study describes trends in the utilization of, spending on, and average per-prescription spending on outpatient antifungal medications individually, in classes (for IFIs ...

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