全部文献期刊学位论文会议报纸专利标准年鉴图书|学者科研项目
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作者:Sven Loebrich , Mingfang Shen , Erika Cohen ...
来源:[J].The AAPS Journal(IF 4.386), 2017, Vol.19 (4), pp.1223-1234Springer
摘要:Antibody-drug-conjugates (ADCs) are an emerging class of biological therapeutics. Mirvetuximab soravtansine is a novel folate receptor alpha (FRα)-targeting ADC which represents a potential new treatment for patients with ovarian and other FRα-positive cancers. Since patient...
作者:Marta Rodriguez-Aller , Davy Guillarme , Alain Beck ...
来源:[J].Journal of Pharmaceutical and Biomedical Analysis(IF 2.947), 2016, Vol.118, pp.393-403Elsevier
摘要:Abstract(#br)The goal of this work is to provide some recommendations for method development in HIC using monoclonal antibodies (mAbs) and antibody-drug conjugates (ADCs) as model drug candidates. The effects of gradient steepness, mobile phase pH, salt concentration and typ...
作者:Alessandra Cusumano , Davy Guillarme , Alain Beck ...
来源:[J].Journal of Pharmaceutical and Biomedical Analysis(IF 2.947), 2016, Vol.121, pp.161-173Elsevier
摘要:Abstract(#br)The goal of this second part was (i) to evaluate the performance of commercially available HIC columns and (ii) to develop a fast and automated “phase system” (i.e. stationary phase and salt type) optimization procedure for the analytical characterization of pro...
作者:Robert E Birdsall , Henry Shion , Frank W Kotch ...
来源:[J].mAbs(IF 5.275), 2015, Vol.7 (6), pp.1036-1044Taylor & Francis
摘要:Cysteine-conjugated antibody-drug conjugates (ADCs) are manufactured using controlled partial reduction and conjugation chemistry with drug payloads that typically occur in intervals of 0, 2, 4, 6, and 8. Control of heterogeneity is of particular importance to the quality of ADC ...
作者:Garrett K. Berger , Kevin Gee , Cassandra Votruba ...
来源:[J].Critical Reviews in Oncology / Hematology(IF 4.637), 2017, Vol.113, pp.8-17Elsevier
摘要:Abstract(#br)Background(#br)CD30 (Ki-1) is a cell membrane protein derived from the tumor necrosis factor (TNF) receptor family. The CD30 antigen has been associated primarily with Hodgkin lymphoma (HL) and systemic anaplastic large cell lymphoma (sALCL). Brentuximab vedotin (BV)...
作者:Balázs Bobály , Giuseppe Marco Randazzo , Serge Rudaz ...
来源:[J].Journal of Chromatography A(IF 4.612), 2017, Vol.1481, pp.82-91Elsevier
摘要:Abstract(#br)The goal of this work was to evaluate the potential of non-linear gradients in hydrophobic interaction chromatography (HIC), to improve the separation between the different homologous species (drug-to-antibody, DAR) of commercial antibody-drug conjugates (ADC). The s...
作者:Michael Adamo , Guoyong Sun , Difei Qiu ...
来源:[J].Journal of Chromatography A(IF 4.612), 2017, Vol.1481, pp.44-52Elsevier
摘要:Abstract(#br)Antibody drug conjugates or ADCs are currently being evaluated for their effectiveness as targeted chemotherapeutic agents across the pharmaceutical industry. Due to the complexity arising from the choice of antibody, drug and linker; analytical methods for release a...
作者:Balázs Bobály , Giuseppe Marco Randazzo , Serge Rudaz ...
来源:[J].Journal of Chromatography A(IF 4.612), 2017, Vol.1481, pp.82-91Elsevier
摘要:Abstract(#br)The goal of this work was to evaluate the potential of non-linear gradients in hydrophobic interaction chromatography (HIC), to improve the separation between the different homologous species (drug-to-antibody, DAR) of commercial antibody-drug conjugates (ADC). The s...
作者:Michael Adamo , Guoyong Sun , Difei Qiu ...
来源:[J].Journal of Chromatography A(IF 4.612), 2017, Vol.1481, pp.44-52Elsevier
摘要:Abstract(#br)Antibody drug conjugates or ADCs are currently being evaluated for their effectiveness as targeted chemotherapeutic agents across the pharmaceutical industry. Due to the complexity arising from the choice of antibody, drug and linker; analytical methods for release a...
作者:Alexandre Goyon , Alain Beck , Jean-Luc Veuthey ...
来源:[J].Journal of Pharmaceutical and Biomedical Analysis(IF 2.947), 2017, Vol.144, pp.242-251Elsevier
摘要:Abstract(#br)To separate proteins solely based on their difference in hydrodynamic volume in size exclusion chromatography (SEC), the ionic strength of the mobile phase has to be increased in order to avoid secondary ionic interactions between proteins and the stationary phase. H...

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