全部文献期刊会议图书|学者科研项目
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作者:Thiago Ferreira de Souza , Thiago Quinaglia A.C. Silva , Felipe Osorio Costa ...
来源:[J].JACC: Cardiovascular Imaging(IF 6.164), 2018, Vol.11 (8), pp.1045-1055
摘要:Abstract(#br)Objectives(#br)The goal of this study was to demonstrate that cardiac magnetic resonance could reveal anthracycline-induced early tissue remodeling and its relation to cardiac dysfunction and left ventricular (LV) atrophy.(#br)Background(#br)Serum biomarkers of car...
作者:Jan Hintzpeter , Jan Moritz Seliger , Jakub Hofman ...
来源:[J].Toxicology and Applied Pharmacology(IF 3.975), 2016, Vol.293, pp.21-29
摘要:... Therefore, we aimed to identify novel and potent natural inhibitors for anthracycline reductases, which enhance the anticancer effect of anthracyclines by preventing the development of anthracycline resistance.(#br)Human enzymes responsible for the reductive metabolism of dau...
作者:Daniel J. Lenihan , Patrick L. Stevens , Mona Massey ...
来源:[J].Journal of Cardiac Failure(IF 3.32), 2016, Vol.22 (6), pp.433-438
摘要:Abstract(#br)Background(#br)Anthracycline chemotherapy is associated with an increased risk of developing heart failure (HF). The current standard for detecting HF or cardiotoxicity during chemotherapy involves episodic cardiac imaging typically at prescribed intervals and there ...
作者:Douglas B. Sawyer , Xuyang Peng , Billy Chen ...
来源:[J].Progress in Cardiovascular Diseases(IF 4), 2010, Vol.53 (2), pp.105-113
摘要:Abstract(#br)Anthracycline antibiotics have saved the lives of many cancer victims in the 50 plus years since their discovery. A major limitation of their use is the dose-limiting cardiotoxicity. Efforts focusing on understanding the biochemical basis for anthracycline cardiac e...
作者:Karolina Matyjaszczyk , Marta Kolonko , Anna Gonciarz-Dytman ...
来源:[J].Journal of Chromatography B(IF 2.487), 2017, Vol.1060, pp.44-52
摘要:Abstract(#br)The thermodynamic acid dissociation constants (pK a1 and pK a2 ) of 16 anthracycline antibiotics, including doxorubicin (DOX) and daunorubicin (DAU), their epimers, epidoxorubicin (EDOX) and epidaunorubicin (EDAU), as well as novel anthracycline derivatives containin...
作者:Shoko Norimura , Keiichi Kontani , Takako Kubo ...
来源:[J].Journal of Cancer Research and Therapeutics(IF 0.761), 2018, Vol.14 (2), pp.409-415
摘要:...Results: The response rates to anthracycline and taxane were 70.5% and 67.2%, respectively. Overall, 25.1% ± 29.7%, 8.32% ± 10.1%, and 16.37% ±17.5% of cancer cells in the tumors studied were positive for B-tub, TOP2A, and TIMP-1 expressions, respectively. However, pos...
作者:R.Y.T Sung , G.Y Huang , M.K Shing ...
来源:[J].International Journal of Cardiology(IF 5.509), 1997, Vol.60 (3), pp.239-248
摘要:Abstract(#br)Using Doppler echocardiography, we studied the left ventricular systolic and diastolic function in 124 healthy control children (group C), 110 oncology patients who had received anthracycline (group A), and 76 oncology patients who had received chemotherapy not incl...
作者:Annemette V. Thougaard , Seppo W. Langer , Bo Hainau ...
来源:[J].Toxicology(IF 4.017), 2010, Vol.269 (1), pp.67-72
摘要:Abstract(#br)The bisdioxopiperazine topoisomerase II catalytic inhibitor dexrazoxane has successfully been introduced into the clinic as an antidote to accidental anthracycline extravasation based on our preclinical mouse studies. The histology of this mouse extravasation model w...
作者:A. Olson , V. Al Jahdami , M. Timmons ...
来源:[J].Cytotherapy(IF 3.055), 2019, Vol.21 (5), pp.S50-S50
摘要:Background & Aim(#br)Cardiomyopathy and cardiovascular toxicities can occur up to 20 years after anthracycline exposure with an incidence of 20%. Anthracycline cardiotoxicity (AC) is mediated by reactive oxygen species. Despite guideline directed medical therapy (GDMT) 52% of AC ...
作者:Marina M.L Fiallo , Arlette Garnier-Suillerot , Berthold Matzanke ...
来源:[J].Journal of Inorganic Biochemistry(IF 3.197), 1999, Vol.75 (2), pp.105-115
摘要:Abstract(#br)The interaction of Fe 3+ with several anthracycline antitumour antibiotics has been reinvestigated. Absorption and circular dichroism (CD) measurements were carried out (i) in aqueous solution and (ii) in semi-aqueous MeOH to avoid the stacking of the anthracycline...

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