全部文献期刊会议图书|学者科研项目
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作者:Lexing Li , Chunxiao Huang , Yulong He ...
来源:[J].Cellular Physiology and Biochemistry(IF 3.415), 2018, Vol.48 (4), pp.1723-1734DOAJ
摘要:... This study was taken to identify the effect of GAS5/miR-23a/ATG3 axis on autophagy and cell viability. Methods: The western blotting assay was used to detecte the protein levels of LC3, mTOR, Beclin-1, ATG3, ATG5-ATG12 complex and p62. The mRNA level of Pre-miR-23a, Pri-miR-2...
作者:Fei Kong , Juan Jin , Xiaolin Lv ...
来源:[J].Biomedicine & Pharmacotherapy(IF 2.068), 2019, Vol.109, pp.716-725Elsevier
摘要:... Furthermore, ATG3 was a target of miR-206, and he effects of miR-206 on hypoxia injury were through targeting ATG3. Besides, overexpression of RMRP activated PI3K/AKT/mTOR pathway in hypoxia-treated H9c2 cells, which were reversed by miR-206 overexpression at the same time. F...
作者:Liang Yang , Xueqiang Peng , Hongyuan Jin ...
来源:[J].Gene(IF 2.196), 2019, Vol.697, pp.94-102Elsevier
摘要:... Then, we confirmed that the effect of PVT1 promoting autophagy was dependent on regulating ATG3 expression. Further investigations revealed that PVT1 could upregulate autophagy-related gene 3 (ATG3) expression by acting as an endogenous sponge of miR-365, which was an inh...
作者:Yunsheng Zhang , Fang Li , Luogen Liu ...
来源:[J].Life Sciences(IF 2.555), 2018, Vol.207, pp.451-460Elsevier
摘要:... Furthermore, we used lentivirus-mediated shRNA to silence ATG3 , ATG5 and ATG7 expression in PC-3 cells to investigate the regulatory mechanisms of salinomycin-induced autophagy.(#br)Key findings(#br)Salinomycin could induce apoptosis and autophagy in PC-3 cells. Interestingl...
作者:Qiu , Zheng , Grace ...
来源:[J].Autophagy(IF 12.042), 2020, Vol.16 (1), pp.183-184Taylor & Francis
摘要:... This process is catalyzed by an E1-E2-E3 trienzyme cascade, in which an E1 enzyme, Atg7, directs Atg8 to its E2 enzyme, Atg3, forming a thioester bond-linked Atg3~ Atg8 intermediate; then the composite E3, Atg12–Atg5-Atg16, interacts with the Atg3~ Atg8 intermediate and p...
作者:Arun K Haldar , Anthony S Piro , Danielle M Pilla ...
来源:[J].PLoS ONE(IF 3.73), 2017, Vol.9 (1)DOAJ
摘要:... Atg5 is part of a protein complex that facilitates the transfer of the ubiquitin-like protein Atg8 from the E2-like conjugation enzyme Atg3 to the lipid phosphatidylethanolamine. Here, we show that Atg3 expression, similar to Atg5 expression, is required for IRG and Gbp prote...
作者:Ke Ma , Wan Fu , Ming Tang ...
来源:[J].Autophagy(IF 12.042), 2017, Vol.13 (3), pp.579-591Taylor & Francis
摘要:ABSTRACT(#br)ATG3 (autophagy-related 3) is an E2-like enzyme essential for autophagy; however, it is unknown whether it has an autophagy-independent function. Here, we report that ATG3 is a relatively stable protein in unstressed cells, but it is degraded in response to DNA-damag...
作者:Juan Gu , Yueping Wang , Xuedong Wang ...
来源:[J].Cellular Physiology and Biochemistry(IF 3.415), 2018, Vol.48 (1), pp.194-207DOAJ
摘要:... RNA immunoprecipitation (RIP) was used to evaluate the relationship between GAS5 and miR-23a, and a dual luciferase reporter gene assay was employed to assess the relationship between ATG3 and miR-23a. A subcutaneous xenograft nude mouse model was generated to examine the rol...
作者:Lin Wang , Jin Song , Jing Zhang ...
来源:[J].Molecular Biology Reports(IF 2.506), 2014, Vol.41 (4), pp.2093-2099Springer
摘要:... ATG3 is the only down regulated gene. This research is to investigate the effect of ATG3 gene over expression by lentivirus on SKM-1 cell line and myelodysplastic syndrome to leukemic transformation. Human SKM-1 cells were transfected with ATG3–GFP recombinant lentivir...
作者:Burgoyne
来源:[J].Autophagy(IF 12.042), 2018, Vol.14 (6), pp.1092-1093Taylor & Francis
摘要:... During active autophagy, LC3 is transferred from the catalytic thiol of ATG7 to the active site thiol of ATG3, where it is conjugated to phosphatidylethanolamine. In our recent study, we show LC3 is bound to the catalytic thiols of inactive ATG3 and ATG7 through a stable thio...

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