全部文献期刊会议图书|学者科研项目
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作者:Kuilong Wang , Wei Huang , Xianan Sang ...
来源:[J].Phytomedicine(IF 2.972), 2020, Vol.68
摘要:...(#br)Hypothesis(#br)ATL-1 exerts therapeutic effect against CRC by disrupting glucose metabolism and cancer stem cell maintenance via AKT/mTOR pathway regulation.(#br)Study design(#br)In vitro studies were performed in COLO205 and HCT116 CRC cell lines and in vivo studies were...
作者:Shanel Dhani , Terisha Ghazi , Savania Nagiah ...
来源:[J].Food and Chemical Toxicology(IF 3.01), 2020, Vol.138
摘要:Abstract(#br)The brain is a highly metabolic organ and requires regulatory mechanisms to meet its high energy demand, with the PI3K/Akt and AMPK signalling pathways being central regulators of cellular energy and metabolism, also making them major targets for the development...
作者:Yue Li , Qihua Xu , Menglin Shi ...
来源:[J].Microvascular Research(IF 2.929), 2020, Vol.129
摘要:... Furthermore, the regulatory mechanism regarding the phosphatidylinositol 3-kinase/protein kinase B (PI3K/Akt) signaling pathway was explored, phosphorylation levels of PI3K and Akt proteins were assessed by Western blot assay, which showed the enhancement of phosphorylation ...
作者:Xiao Gu , Xiaocui Yao , Dengtao Liu
来源:[J].Cellular Signalling(IF 4.304), 2020, Vol.70
摘要:... The regulatory effect of miR-335-5p on inflammation with the involvement of the AKT signaling pathway was also analyzed with the expression of inflammatory cytokines and AKT signaling pathway-related factors measured. It was indicated that miR-335-5p regulated the TPX2 gen...
作者:Feng He , Laura Antonucci , Shinichiro Yamachika ...
来源:[J].Journal of Hepatology(IF 9.858), 2020
摘要:... Insulin acts via AKT, but how other challenges cause hepatomegaly is unknown.(#br)Methods(#br)Since many hepatomegaly-inducing toxicants and stressors activate NRF2, we examined the effect of NRF2 activation on liver size and metabolism using a conditional allele encoding a ...
作者:Lina Sun , Kai Cui , Fuyan Xing ...
来源:[J].Behavioural Brain Research(IF 3.327), 2020, Vol.379
摘要:... In current study, we aimed to address how treadmill exercise benefit adult hippocampal neurogenesis in PTSD model and the underlying molecular mechanism related with Akt signaling. PTSD was induced by exposure to aggressor and treatments were conducted with different intensit...
作者:Chen-Yuan Chiu , Min-Ni Chung , Kuo-Cheng Lan ...
来源:[J].Toxicology in Vitro(IF 2.65), 2020, Vol.65
摘要:... Submicromolar-concentration As 2 O 3 dose-dependently triggered C2C12 myotube atrophy and increased the protein expressions of atrogenes Atrogin1 and MuRF1 and inhibited the upstream phosphorylated proteins Akt and FoxO1, while As 2 O 3 dose-dependently increased AMPK phosph...
作者:Na Xing , Fei Xing , Yanna Li ...
来源:[J].Life Sciences(IF 2.555), 2020, Vol.247
摘要:... miR-34a expression was detected using RT-qPCR, while the binding of miR-34a and Sirtuin1 (SIRT1) was identified with dual luciferase reporter gene assay, and the activation of PI3K/Akt signaling pathway was detected. Additionally, hippocampal neurons were cultured in vitro ...
作者:Qian Wang , Shu-Ping Yan , Dan-Xia Chu ...
来源:[J].Molecular Therapy - Nucleic Acids, 2020, Vol.19, pp.304-317
摘要:...6, and LY294002 (an inhibitor for the phosphatidylinositol 3-kinase [PI3K]/Akt [serine/threonine kinase] axis) were introduced in a respective manner to treat the HeLa cells in order to analyze their effects on cellular activities in vitro . Nude mice with xenograft tumors wer...
作者:Yanqiong Zhang , Xia Mao , Wenjia Chen ...
来源:[J].Molecular Therapy - Nucleic Acids, 2020, Vol.19, pp.890-904
摘要:... Herein, a total of 161 FBRP candidate targets against HCC were identified according to the topological importance in the “hepatic fibrosis-cirrhosis-cancer axis-related gene-FBRP putative target” network, and mostly enriched in phosphatidylinositol 3-kinase (PI3K)/AKT...

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