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作者:Massimiliano Runfola , Simona Sestito , Lorenza Bellusci ...
来源:[J].European Journal of Medicinal Chemistry(IF 3.499), 2020, Vol.188Elsevier
摘要:... Herein, we describe the drug discovery process sustained by ADME-Toxicity analysis that led us to identify novel agonists with selectivity for the isoform TRβ and an acceptable off-target and absorption, distribution metabolism, excretion and toxicity (ADME-Tox) profile. W...
作者:Salam Pradeep Singh , Bolin Kumar Konwar , Rajib Lochan Bezbaruah ...
来源:[J].Medicinal Chemistry Research(IF 1.612), 2013, Vol.22 (10), pp.4755-4765Springer
摘要:... Further, the top docked compounds at the active site of the DHDPS enzyme were analysed for ADME-Toxicity prediction.
作者:Loredana Salerno , Emanuele Amata , Giuseppe Romeo ...
来源:[J].European Journal of Medicinal Chemistry(IF 3.499), 2018, Vol.148, pp.54-62Elsevier
摘要:Abstract(#br)Here we report the design, synthesis, and molecular modeling of new potent and selective imidazole-based HO-1 inhibitors in which the imidazole nucleus and the hydrophobic groups are linked by a phenylethanolic spacer. Most of the tested compounds showed a good inhib...
作者:Dilip K. Tosh , Janak Padia , Daniela Salvemini ...
来源:[J].Purinergic Signalling(IF 2.635), 2015, Vol.11 (3), pp.371-387Springer
摘要:Abstract(#br)We reported that 2-(3,4-difluorophenylethynyl)- N 6-3-chlorobenzyl ( N )-methanocarba adenosine derivative 1 (MRS5698) binds selectively to human and mouse A3 adenosine receptors (A3ARs, K i 3 nM). It is becoming an ...
作者:Pone Kamdem Boniface , Surjeet Verma , Aparna Shukla ...
来源:[J].Natural Product Research(IF 1.031), 2014, Vol.28 (23), pp.2203-2207Taylor & Francis
摘要:This study was undertaken to evaluate the efficiency of extract, fractions and pure molecules from Spathodea campanulata (SC) towards inflammation. Polarity-based extracts of SC were found active in stabilising red blood cell (RBC) membrane indicating anti-inflammatory poten...
作者:Vilas Belekar , Anup Shah , Prabha Garg
来源:[J].Molecular Diversity(IF 2.861), 2013, Vol.17 (1), pp.97-110Springer
摘要:Abstract(#br)Therapeutic agents exert their pharmacological and adverse effects by interacting with molecular targets. Even if drug molecules are intended to interact with specific targets in a desirable manner, they are often found to bind to other targets. Nowadays, resear...
作者:Khaled F. Greish , Loredana Salerno , Reem Al Zahrani ...
来源:[J].Molecules(IF 2.428), 2018, Vol.23 (5)MDPI
摘要:In this paper, the design, synthesis, and molecular modeling of a new azole-based HO-1 inhibitors was reported, using compound 1 as a lead compound, in which an imidazole moiety is linked to a hydrophobic group by means of an ethanolic spacer. The tested compounds showed a g...
作者:Lutfi Chabib , Rizki Awaluddin , Zullies Ikawati ...
来源:[J].International Journal of Pharmacy and Pharmaceutical Sciences, 2017, Vol.9 (9), pp.16-21IAS
摘要:Objective: The objective of this research was to examine the activity and cytokine inhibitory mechanism of curcumin analog compound against multiple protein targets in a patient with rheumatoid arthritis (RA) and identify the absorption, distribution, metabolism, excretion and toxicity (ADME-toxicity...
作者:Greish Khaled F , Salerno Loredana , Al Zahrani Reem ...
来源:[J].Molecules (Basel, Switzerland)(IF 2.428), 2018, Vol.23 (5)PubMed
摘要:In this paper, the design, synthesis, and molecular modeling of a new azole-based HO-1 inhibitors was reported, using compound 1 as a lead compound, in which an imidazole moiety is linked to a hydrophobic group by means of an ethanolic spacer. The tested compounds showed a good i...
作者:Salam Pradeep Singh , Ningthoujam Indrajit Singh , Khumukcham Nongalleima ...
来源:[J].Network Modeling Analysis in Health Informatics and Bioinformatics, 2018, Vol.7 (1), pp.1-8Springer
摘要:Abstract(#br)The inhibitor of kappaB kinase beta (IKK-β) is an important target for the therapeutic treatment of cancer and inflammatory diseases. On the other hand, zerumbone an isolate from Zingiber zerumbet has become an important molecule for targeting various cancer dru...

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