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作者:Julien Petrignet , Emilie Thiery , Laurence Silpa ...
来源:[J].Synthesis(IF 2.5), 2014, pp.-
摘要:New and efficient methods for the synthesis of 7-substituted-4-trifluoromethylpyrimido[1,2-b]pyridazin-2-one derivatives using either two-step Suzuki/heterocyclization, or two-step heterocyclization/substitution sequences are developed. A variety of substituted products are obtai...
作者:Marilena Vasilescu , F. Dumitrascu , H. Lemmetyinen ...
来源:[J].Journal of Fluorescence(IF 1.789), 2004, Vol.14 (4), pp.443-450
摘要:Abstract(#br)Three new mesoionic oxazolo[3,2-b]pyridazin-2-one derivatives, in different solutions have been investigated by UV-Vis absorption, steady-state and time-resolved fluorescence methods. The effect of substituents on the extension of conjugation of the π-electrons fr...
作者:Vasilescu Marilena , Dumitrascu F , Lemmetyinen H ...
来源:[J].Journal of fluorescence(IF 1.789), 2004, Vol.14 (4), pp.443-50
摘要:Three new mesoionic oxazolo[3,2-b]pyridazin-2-one derivatives, in different solutions have been investigated by UV-Vis absorption, steady-state and time-resolved fluorescence methods. The effect of substituents on the extension of conjugation of the pi-electrons from mesoionic ox...
作者:Ruebsam Frank , Webber Stephen E , Tran Martin T ...
来源:[J].Bioorganic & medicinal chemistry letters, 2008, Vol.18 (12), pp.3616-21
摘要:Pyrrolo[1,2-b]pyridazin-2-one analogs were discovered as a novel class of inhibitors of genotype 1 HCV NS5B polymerase. Structure-based design led to the discovery of compound 3 k, which displayed potent inhibitory activities in biochemical and replicon assays (IC(50) (1b)<10nM; ...
作者:Ruebsam Frank , Sun Zhongxiang , Ayida Benjamin K ...
来源:[J].Bioorganic & medicinal chemistry letters, 2008, Vol.18 (18), pp.5002-5
摘要:Hexahydro-pyrrolo- and hexahydro-1H-pyrido[1,2-b]pyridazin-2-one analogs were discovered as a novel class of inhibitors of genotype 1 HCV NS5B polymerase. Among these, compound 4c displayed potent inhibitory activities in biochemical and replicon assays (IC(50) (1b) <10 nM; EC(50...

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