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作者:Maxwell J Roeske , Eric M Camino , Sumant Grover ...
来源:[J].eLife, 2018, Vol.7eLife科学出版社
摘要:Gene expression evolution through gene regulatory network (GRN) changes has gained appreciation as a driver of morphological evolution. However, understanding how GRNs evolve is hampered by finding relevant cis -regulatory element (CRE) mutations, and interpreting the protei...
作者:Nicole Toepfner , Christoph Herold , Oliver Otto ...
来源:[J].eLife, 2018, Vol.7eLife科学出版社
摘要:Blood is arguably the most important bodily fluid and its analysis provides crucial health status information. A first routine measure to narrow down diagnosis in clinical practice is the differential blood count, determining the frequency of all major blood cells. What is l...
作者:Marianne Burbage , Francesca Gasparrini , Shweta Aggarwal ...
来源:[J].eLife, 2018, Vol.7eLife科学出版社
摘要:Wiskott-Aldrich syndrome (WAS) is an immune pathology associated with mutations in WAS protein (WASp) or in WASp interacting protein (WIP). Together with the small GTPase Cdc42 and other effectors, these proteins participate in the remodelling of the actin network downstream of B...
作者:Philippe Bun , Serge Dmitrieff , Julio M Belmonte ...
来源:[J].eLife, 2018, Vol.7eLife科学出版社
摘要:While contraction of sarcomeric actomyosin assemblies is well understood, this is not the case for disordered networks of actin filaments (F-actin) driving diverse essential processes in animal cells. For example, at the onset of meiosis in starfish oocytes a contractile F-actin ...
作者:Guillermo Rodrigo , Mario A Fares
来源:[J].eLife, 2018, Vol.7eLife科学出版社
摘要:The population genetic mechanisms governing the preservation of gene duplicates, especially in the critical very initial phase, have remained largely unknown. Here, we demonstrate that gene duplication confers per se a weak selective advantage in scenarios of fitness trade-offs. ...
作者:Christopher A Natale , Jinyang Li , Junqian Zhang ...
来源:[J].eLife, 2018, Vol.7eLife科学出版社
摘要:Female sex and history of prior pregnancies are associated with favorable melanoma outcomes. Here, we show that much of the melanoma protective effect likely results from estrogen signaling through the G protein-coupled estrogen receptor (GPER) on melanocytes. Selective GPER acti...
作者:Vanessa M Brown , Lusha Zhu , John M Wang ...
来源:[J].eLife, 2018, Vol.7eLife科学出版社
摘要:Disproportionate reactions to unexpected stimuli in the environment are a cardinal symptom of posttraumatic stress disorder (PTSD). Here, we test whether these heightened responses are associated with disruptions in distinct components of reinforcement learning. Specifically...
作者:Daniel R Kick , David J Schulz
来源:[J].eLife, 2018, Vol.7eLife科学出版社
摘要:Experiments on neurons in the heart system of the leech reveal why rhythmic behaviors differ between individuals.
作者:J Graham Ruby , Megan Smith , Rochelle Buffenstein
来源:[J].eLife, 2018, Vol.7eLife科学出版社
摘要:The longest-lived rodent, the naked mole-rat ( Heterocephalus glaber) , has a reported maximum lifespan of >30 years and exhibits delayed and/or attenuated age-associated physiological declines. We questioned whether these mouse-sized, eusocial rodents conform to Gompertzian...

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