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作者:Kannan Venugopal , Elisabeth Werkmeister , Nicolas Barois ...
来源:[J].PLOS Pathogens(IF 9.127), 2017, Vol.13 (4)PLOS
摘要:Toxoplasma gondii possesses a highly polarized secretory system, which efficiently assembles de novo micronemes and rhoptries during parasite replication. These apical secretory organelles release their contents into host cells promoting parasite invasion and survival. Using...
作者:Teja Shidore , Corey D. Broeckling , Jay S. Kirkwood ...
来源:[J].PLOS Pathogens(IF 9.127), 2017, Vol.13 (6)PLOS
摘要:Gram-negative bacterial pathogens of plants and animals employ type III secreted effectors to suppress innate immunity. Most characterized effectors work through modification of host proteins or transcriptional regulators, although a few are known to modify small molecule ta...
作者:Nelson D. Glennie , Susan W. Volk , Phillip Scott
来源:[J].PLOS Pathogens(IF 9.127), 2017, Vol.13 (4)PLOS
摘要:Tissue-resident memory T cells are required for establishing protective immunity against a variety of different pathogens, although the mechanisms mediating protection by CD4+ resident memory T cells are still being defined. In this study we addressed this issue w...
作者:Érika Machado de Salles , Maria Nogueira de Menezes , Renan Siqueira ...
来源:[J].PLOS Pathogens(IF 9.127), 2017, Vol.13 (8)PLOS
摘要:A complete understanding of the mechanisms underlying the acquisition of protective immunity is crucial to improve vaccine strategies to eradicate malaria. However, it is still unclear whether recognition of damage signals influences the immune response to Plasmodium infecti...
作者:Maria Marta Figueiredo , Pedro Augusto Carvalho Costa , Suelen Queiroz Diniz ...
来源:[J].PLOS Pathogens(IF 9.127), 2017, Vol.13 (7)PLOS
摘要:Although the importance of humoral immunity to malaria has been established, factors that control antibody production are poorly understood. Follicular helper T cells (Tfh cells) are pivotal for generating high-affinity, long-lived antibody responses. While it has been propo...
作者:Laura V. Glaser , Simone Rieger , Sybille Thumann ...
来源:[J].PLOS Pathogens(IF 9.127), 2017, Vol.13 (10)PLOS
摘要:Epstein-Barr virus (EBV) infection converts resting human B cells into permanently proliferating lymphoblastoid cell lines (LCLs). The Epstein-Barr virus nuclear antigen 2 (EBNA2) plays a key role in this process. It preferentially binds to B cell enhancers and establishes a spec...
作者:Kari Debbink , John T. McCrone , Joshua G. Petrie ...
来源:[J].PLOS Pathogens(IF 9.127), 2017, Vol.13 (1)PLOS
摘要:While influenza virus diversity and antigenic drift have been well characterized on a global scale, the factors that influence the virus’ rapid evolution within and between human hosts are less clear. Given the modest effectiveness of seasonal vaccination, vaccine-induced an...
作者:Ravin Seepersaud , David Sychantha , Barbara A. Bensing ...
来源:[J].PLOS Pathogens(IF 9.127), 2017, Vol.13 (8)PLOS
摘要:The serine-rich repeat (SRR) glycoproteins are a family of adhesins found in many Gram-positive bacteria. Expression of the SRR adhesins has been linked to virulence for a variety of infections, including streptococcal endocarditis. The SRR preproteins undergo intracellular glyco...
作者:Mathieu Iampietro , Patrick Younan , Andrew Nishida ...
来源:[J].PLOS Pathogens(IF 9.127), 2017, Vol.13 (5)PLOS
摘要:Fatal outcomes of Ebola virus (EBOV) infections are typically preceded by a ‘sepsis-like’ syndrome and lymphopenia despite T cells being resistant to Ebola infection. The mechanisms that lead to T lymphocytes death remain largely unknown; however, the degree of lymphopenia i...
作者:Jonathan B. Wang , Hsiao-Ling Lu , Raymond J. St. Leger
来源:[J].PLOS Pathogens(IF 9.127), 2017, Vol.13 (3)PLOS
摘要:Individuals vary extensively in the way they respond to disease but the genetic basis of this variation is not fully understood. We found substantial individual variation in resistance and tolerance to the fungal pathogen Metarhizium anisopliae Ma549 using the Drosophila melanoga...

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