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作者:Zoltán Bódi , Zoltán Farkas , Dmitry Nevozhay ...
来源:[J].PLOS Biology(IF 11.452), 2017, Vol.15 (5)PLOS
摘要:Genetically identical cells frequently display substantial heterogeneity in gene expression, cellular morphology and physiology. It has been suggested that by rapidly generating a subpopulation with novel phenotypic traits, phenotypic heterogeneity (or plasticity) accelerates the...
作者:Stefano Di Biase , Hong Seok Shim , Kyung Hwa Kim ...
来源:[J].PLOS Biology(IF 11.452), 2017, Vol.15 (3)PLOS
摘要:Fasting reduces glucose levels and protects mice against chemotoxicity, yet drugs that promote hyperglycemia are widely used in cancer treatment. Here, we show that dexamethasone (Dexa) and rapamycin (Rapa), commonly administered to cancer patients, elevate glucose and sensi...
作者:Sebastian Kirchner , Zhiwei Cai , Robert Rauscher ...
来源:[J].PLOS Biology(IF 11.452), 2017, Vol.15 (5)PLOS
摘要:Synonymous single nucleotide polymorphisms (sSNPs) are considered neutral for protein function, as by definition they exchange only codons, not amino acids. We identified an sSNP that modifies the local translation speed of the cystic fibrosis transmembrane conductance regulator ...
作者:Mihir Vohra , George A. Lemieux , Lin Lin ...
来源:[J].PLOS Biology(IF 11.452), 2017, Vol.15 (8)PLOS
摘要:In species ranging from humans to Caenorhabditis elegans , dietary restriction (DR) grants numerous benefits, including enhanced learning. The precise mechanisms by which DR engenders benefits on processes related to learning remain poorly understood. As a result, it is uncl...
作者:Lu Huang , Yongjie Zhang , Chenguang Xu ...
来源:[J].PLOS Biology(IF 11.452), 2017, Vol.15 (8)PLOS
摘要:As the central hub of the metabolism machinery, the mammalian target of rapamycin complex 2 (mTORC2) has been well studied in lymphocytes. As an obligatory component of mTORC2, the role of Rictor in T cells is well established. However, the role of Rictor in B cells still re...
作者:Michelle C. Dunn , Philip E. Bourne
来源:[J].PLOS Biology(IF 11.452), 2017, Vol.15 (7)PLOS
摘要:This article describes efforts at the National Institutes of Health (NIH) from 2013 to 2016 to train a national workforce in biomedical data science. We provide an analysis of the Big Data to Knowledge (BD2K) training program strengths and weaknesses with an eye toward futur...
作者:Hieu D. Hoang , Michael A. Miller
来源:[J].PLOS Biology(IF 11.452), 2017, Vol.15 (6)PLOS
摘要:The sperm’s crucial function is to locate and fuse with a mature oocyte. Under laboratory conditions, Caenorhabditis elegans sperm are very efficient at navigating the hermaphrodite reproductive tract and locating oocytes. Here, we identify chemosensory and oxygen-sensing ci...
作者:Joana Lourenço , Alberto Bacci
来源:[J].PLOS Biology(IF 11.452), 2017, Vol.15 (1)PLOS
摘要:One outstanding difference between Homo sapiens and other mammals is the ability to perform highly complex cognitive tasks and behaviors, such as language, abstract thinking, and cultural diversity. How is this accomplished? According to one prominent theory, cognitive complexity...
作者:Xiao Li , Jessilyn Dunn , Denis Salins ...
来源:[J].PLOS Biology(IF 11.452), 2017, Vol.15 (1)PLOS
摘要:A new wave of portable biosensors allows frequent measurement of health-related physiology. We investigated the use of these devices to monitor human physiological changes during various activities and their role in managing health and diagnosing and analyzing disease. By recordi...
作者:Beatriz Albuixech-Crespo , Laura López-Blanch , Demian Burguera ...
来源:[J].PLOS Biology(IF 11.452), 2017, Vol.15 (4)PLOS
摘要:All vertebrate brains develop following a common Bauplan defined by anteroposterior (AP) and dorsoventral (DV) subdivisions, characterized by largely conserved differential expression of gene markers. However, it is still unclear how this Bauplan originated during evolution. We s...

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