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作者:Alpana Tripathi , Gopal ji Srivastavaa , Sashank Srivastava ...
来源:[J].Chemical Biology Letters, 2016, Vol.2 (2), pp.30-40综合科学出版社
摘要:Urinary stone disease has beenprevalent in human beings from many centuries. It has affected up to a quarter of population in certain geographic area and hence poses a significant health problem. Approx 85% human stones are calcium stones comprising of oxalate and phosphate,...
作者:Rajneesh Kaur , Raman Singh , Kuldeep Singh
来源:[J].Chemical Biology Letters, 2016, Vol.3 (1), pp.18-31综合科学出版社
摘要:1,5-Benzothiazepine nucleus is present in a number of clinically used drugs such as diltiazem, clentiazem, thiazesim, quetiapine, and clothiapine. 1,5-Benzothiazepine can be easily introduced in the molecule having 2-aminothiophenol moiety. This article considers various targets ...
作者:Poonam Bhargava , Nisha Aggarwal
来源:[J].Chemical Biology Letters, 2016, Vol.2 (2), pp.22-29综合科学出版社
摘要:Dengue virus infection is a serious threat to global health since an estimated 2.5 billion people worldwide are at risk for epidemic transmission. Dengue virus (DENV) is mosquito-borne arboviruses responsible for causing acute systemic diseases and grievous health conditions in h...
作者:Avnish Kumar Arora , Kuldeep Singh , Vivek Sheel Jaswal ...
来源:[J].Chemical Biology Letters, 2016, Vol.3 (1), pp.9-17综合科学出版社
摘要:Life has evolved approximately 3.7 billion years ago on Earth while the Earth itself was formed some 4.6 billion years ago. So it was the time of 0.9 billion years in which chemical reactions took place and formation of first living cell occurred. There are various views on origi...
作者:Saptarshi Hazra , Sharmila Chattopadhyay
来源:[J].Chemical Biology Letters, 2016, Vol.3 (1), pp.1-8综合科学出版社
摘要:Lignans are the natural products that are specifically made up of two hydroxycinmoyl alcohol units which are joined by C8 side chain. Lignans are originated from the same precursor as lignins but lignans are formed only by stereospecific coupling of monolignol unlike of lign...
作者:Zane Ferreira , Ademola Ayeleso , Emmanuel Mukwevho
来源:[J].Chemical Biology Letters, 2014, Vol.1 (2), pp.66-76综合科学出版社
摘要:The pathogenesis of obesity, insulin resistance and type 2 diabetes can be traced to impaired carbohydrate and lipid metabolism. Carbohydrate and lipid metabolism heavily depend on the mitochondria, which itself is regulated by NRF-1. These metabolic pathways are controlled throu...
作者:Subashini Sekar , Pugalendi Viswanathan K , Baskaran Kishnan ...
来源:[J].Chemical Biology Letters, 2015, Vol.2 (1), pp.6-11综合科学出版社
摘要:Diabetes is a growing health concern worldwide and now emerging as an epidemic world over. The management of diabetes is still a major challenge. Diabetes is characterized by excessive blood sugar due to body’s failure to produce insulin or the consequence of insulin resista...
作者:Brijesh Rathi, Ph.D. , Prem Prakash Sharma , R P Singh
来源:[J].Chemical Biology Letters, 2014, Vol.1 (1), pp.11-13综合科学出版社
摘要:Hydroxyethylamine (HEA) based small molecules have extensively been evaluated for their antimalarial properties. HEA scaffold enabled generation of numerous chemical libraries with significant antimalarial activity. Besides, the tetrahedral HEA scaffold has been explored for the ...
作者:Viacheslav Trush , Sergiy Cherenok , Vsevolod Tanchuk ...
来源:[J].Chemical Biology Letters, 2015, Vol.2 (1), pp.1-5综合科学出版社
摘要:Protein tyrosine phosphatase 1B (PTP1B) is known to be implicated in insulin resistance, and inhibitors of PTP1B were supposed to be useful to regulate insulin and leptin signalling pathways. In this paper, calix[4]arene mono- and bis-α-ketophosphonic acids were tested in vi...
作者:Nikesh Gupta , Chetna Gupta , Sandeep Sharma ...
来源:[J].Chemical Biology Letters, 2015, Vol.2 (2), pp.41-44综合科学出版社
摘要:This study investigates an efficient and sustainable route of Ag-NPs preparation using leaf extracts of two plants, Ocimum tenuiflorum (tulsi) and Garcinia mangostana (mangosteen), well adorned for their wide availability and medicinal property. Silver nanoparticles (Ag-NPs)...

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