De Gruyter期刊
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作者:Wei Hu , Wen-Bing Jiang
来源:[J].Acta Pharmaceutica(IF 1.162), 2014, Vol.64 (1), pp.105-115De Gruyter
摘要:Abstract C57BL/6 mice with dilated cardiomyopathy (DCM) were randomly divided to receive placebo or pitavastatin at a dose of 1 or 3 mg kg-1d-1. After 8 weeks treatment, mice with dilated cardiomyopathy developed serious cardiac dysfunction characterized by ...
作者:Rehab Mohammad Yusif , Irhan Ibrahim Abu Hashim , Marwa Salah El-Dahan
来源:[J].Acta Pharmaceutica(IF 1.162), 2014, Vol.64 (1), pp.89-104De Gruyter
摘要:Abstract Eudragit E (EE)-sodium alginate (SA) polyelectrolyte complexes (PECs) were prepared at pH 4 and 5.8 using sodium alginate of high (SAH) and low viscosity (SAL). The optimum EE-SA complexation mass ratio was determined using viscosity measurements. Interactions between EE...
作者:Nina Brvar , Sylvain Lachance , Ann Lévesque ...
来源:[J].Acta Pharmaceutica(IF 1.162), 2014, Vol.64 (1), pp.45-62De Gruyter
摘要:Abstract Two randomized, single dose, 2-period, 2-sequence crossover studies were conducted to evaluate the comparative bioavailability of two clopidogrel formulations under fasting and fed conditions. Assessment of bioequivalence was based upon measurement of plasma concent...
作者:Gamal Mohamed El Maghraby , Ehab Mostafa Elzayat , Fars Kaed Alanazi
来源:[J].Acta Pharmaceutica(IF 1.162), 2014, Vol.64 (1), pp.29-44De Gruyter
摘要:Abstract Alginate vehicles are capable of forming a gel matrix in situ when they come into contact with gastric medium in the presence of calcium ions. However, the gel structure is pH dependent and can break after gastric emptying, leading to dose dumping. The aim of this work w...
作者:Irena Žuntar , Roberta Petlevski , Slavica Dodig ...
来源:[J].Acta Pharmaceutica(IF 1.162), 2014, Vol.64 (1), pp.117-129De Gruyter
摘要:Abstract The aim of this study was to test the hypothesis that glutathione- S-transferase (GST) genotypes were associated with COPD. GSTP1, GSTM1 and GSTT1 genotypes were determined by DNA methods and GST activity spectrophotometrically in older male Caucasian Croats (non- -smoke...
作者:Bahia Abbas Moussa , Marianne Alphonse Mahrouse , Mahmoud Ali Hassan ...
来源:[J].Acta Pharmaceutica(IF 1.162), 2014, Vol.64 (1), pp.15-28De Gruyter
摘要:Abstract Quinone-based fluorophores and enhanced native fluorescence techniques were applied for a fast quantitative analysis of gemifloxacin mesylate (GEM) and linezolid (LIN) in pharmaceutical formulations. For this purpose, three sensitive, accurate and precise spectroflu...
作者:Anna Wiktorowska-Owczarek
来源:[J].Acta Pharmaceutica(IF 1.162), 2014, Vol.64 (1), pp.131-138De Gruyter
摘要:Abstract Diclofenac belongs to non-steroidal anti-inflammatory drugs (NSAIDs) and non-selective COX inhibitors. The aim of this study was to examine the effect of diclofenac on endothelial cell proliferation under the influence of hypoxia or inflammatory conditions. Another ...
作者:Aleksandra Stojković , Lidia Tajber , Krzysztof J. Paluch ...
来源:[J].Acta Pharmaceutica(IF 1.162), 2014, Vol.64 (1), pp.77-88De Gruyter
摘要:Abstract Ciprofloxacin bioavailability may be reduced when ciprofloxacin is co-administered with metallic ion containing preparations. In our previous study, physicochemical interaction between ciprofloxacin and ferrous sulphate was successfully simulated in vitro. In the pr...
作者:Ibrahim A. Darwish , Tanveer A. Wani , Nasr Y. Khalil ...
来源:[J].Acta Pharmaceutica(IF 1.162), 2014, Vol.64 (1), pp.63-75De Gruyter
摘要:Abstract The study describes the development and validation of a new microwell-based spectrophotometric assay for determination of olmesartan medoxomil (OLM) in tablets. The formation of a colored charge-transfer (CT) complex between OLM as an n-electron donor and 2,3-dichlo...
作者:Tomislav Jednačak , Aden Hodzic , Otto Scheibelhofer ...
来源:[J].Acta Pharmaceutica(IF 1.162), 2014, Vol.64 (1), pp.1-13De Gruyter
摘要:Abstract Crystallization of the drug entacapone from binary solvent mixtures was monitored in situ using a Raman optical probe. The recorded Raman spectra and statistical analysis, which included the principal components method and indirect hard modeling made it possible to estim...

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