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作者:Yueh-Min Lin , Sudhir Pandey ...
来源:[J].PLOS ONE(IF 3.73), 2018, Vol.13 (5)PLOS
摘要:Earlier studies have shown that estrogen possess protective function against the development of pathological cardiac hypertrophy. However, the molecular mechanisms of estrogens (E2) protective effect are poorly understood. Additionally, abnormal activation of β-adrenergic si...
作者:Yueh-Min Lin , Wen-Wei Sung ...
来源:[J].PLOS ONE(IF 3.73), 2015, Vol.10 (11)PLOS
摘要:PD-L1 has been widely demonstrated to contribute to failed antitumor immunity. Blockade of PD-L1 with monoclonal antibody could modulate the tumor immune environment to augment immunotherapy. PD-L1 expression is also detected in several types of cancer and is associated with poor...
作者:... Li-Sung Hsu , Yueh-Min Lin , Shih-Li Su
来源:[J].PLOS ONE(IF 3.73), 2014, Vol.9 (1)PLOS
摘要:Caveolins are an essential component of cholesterol-rich invaginations of the plasma membrane known as caveolae. These flask-shaped, invaginated structures participate in a number of important cellular processes, including vesicular transport, cholesterol homeostasis, and si...
作者:... Li-Sung Hsu , Yueh-Min Lin , Shih-Li Su
来源:[J].PLOS ONE(IF 3.73), 2016, Vol.11 (4)PLOS
摘要:Caveolin-1 (CAV-1) participates in regulating vesicular transport, signal transduction, tumor progression, and cholesterol homeostasis. In the present study, we tested the hypothesis that CAV-1 improves dyslipidemia, inhibits cyclophilin A (CypA)- mediated ROS production, pr...
作者:Yueh-Min Lin , Shiow-Lian Catherine Jin ...
来源:[J].PLOS ONE(IF 3.73), 2014, Vol.9 (1)PLOS
摘要:Hepatocarcinogenesis commonly involves the gradual progression from hepatitis to fibrosis and cirrhosis, and ultimately to hepatocellular carcinoma (HCC). Endothelin 1 ( Edn1 ) has been identified as a gene that is significantly up-regulated in HBx-induced HCC in mice. In this st...
作者:Yueh-Min Lin , Mu-Kuan Chen ...
来源:[J].PLOS ONE(IF 3.73), 2012, Vol.7 (11)PLOS
摘要:Interleukin 6 (IL6) plays an important role in immunoregulation and tumorigenesis in human cancers. Oral squamous cell carcinoma (OSCC) is a malignant tumor of the oral cavity with a male predominant tendency and a poor clinical prognosis. Due to the relatively few cases in femal...

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