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作者:... Meng Li , Xuming Deng , Jianfeng Wang
来源:[J].Antonie van Leeuwenhoek(IF 2.072), 2017, Vol.110 (8), pp.1069-1075Springer
摘要:Streptococcus pneumoniae (the pneumococcus) is an opportunistic pathogen responsible for several human diseases, including acute otitis media, pneumonia, sepsis and bacterial meningitis, and possesses numerous virulence factors associated with pneumococcal infection and pathogene...
作者:... Wenhua Li , Xuming Deng , Jianfeng Wang
来源:[J].Applied Microbiology and Biotechnology(IF 3.689), 2017, Vol.101 (17), pp.6697-6703Springer
摘要:α-Toxin, one of the best known pore-forming proteins produced by Staphylococcus aureus ( S. aureus ), is a critical virulence factor in multiple infections. The necessity of α-toxin for S. aureus pathogenicity suggests that this toxin is an important target for the developme...
作者:Xuming Deng , Tiedong Wang
来源:[J].Biotechnology Letters(IF 1.853), 2016, Vol.38 (8), pp.1341-1347Springer
摘要:Abstract(#br) Objectives(#br)To use molecular docking and dynamic simulation to investigate the inhibitory action of chlorogenic acid (CHA) and its analogues against sortase A of Staphylococcus aureus .(#br) Results(#br)Five novel, natural inhibitors with different activitie...
作者:Xuming Deng , Zhenguo Yang
来源:[J].World Journal of Microbiology and Biotechnology(IF 1.262), 2017, Vol.33 (1), pp.1-5Springer
摘要:Abstract(#br)We reported the inhibition of α-Hemolysin (Hla) production in methicillin-resistant Staphylococcus aureus USA300 by osthole and further investigated the combination of osthole and baicalin in the treatment of staphylococcal pneumonia. Using cytotoxicity assays a...
作者:... Xue Xu , Hongyu Li , Xuming Deng
来源:[J].Inflammation Research(IF 1.964), 2012, Vol.61 (7), pp.749-758Springer
摘要:Abstract(#br) Objective(#br)We investigated whether roxithromycin reduces ovalbumin-specific allergic asthma symptoms in mice, and we further investigated the inhibitory mechanism of roxithromycin in ovalbumin-specific allergic asthma.(#br) Methods(#br)Mice were divided into...
作者:Xuming Deng , Shili Sun ...
来源:[J].Molecular Biology Reports(IF 2.506), 2018, Vol.45 (5), pp.689-697Springer
摘要:Abstract(#br)The effects of certain tea components on the prevention of obesity in humans have been reported recently. However, whether Yinghong NO. 9 black tea consumption has beneficial effects on obesity are not known. Here, we obtained a Yinghong NO. 9 black tea infusion...
作者:... Guizhen Wang , Xuming Deng , Xiaodi Niu
来源:[J].Journal of Molecular Modeling(IF 1.984), 2019, Vol.25 (5), pp.1-11Springer
摘要:Abstract(#br)The treatment of bacterial infections is currently threatened by the emergence of pathogenic bacteria producing β-lactamase, which catalyzes the hydrolysis of β-lactams. Although the hydrolysis of the substrate nitrocefin by a metallo-β-lactamase, namely β-lacta...
作者:... Xiao Chu , Jianhua Li , Xuming Deng
来源:[J].Inflammation Research(IF 1.964), 2011, Vol.60 (6), pp.589-596Springer
摘要:Abstract(#br) Background and objective(#br)Asthma is an inflammatory disease of the lungs that is characterised by increased inflammatory cell infiltration into the airways and poor respiratory function. Ivermectin is a semi-synthetic derivative of a family of macrocyclic lactone...
作者:... Bowen Liu , Xuming Deng , Liping Peng
来源:[J].Antonie van Leeuwenhoek(IF 2.072), 2015, Vol.108 (2), pp.383-389Springer
摘要:Abstract(#br) Staphylococcus aureus is a significant human pathogen that causes a wide range of diseases. Alpha-hemolysin (Hla), a pore-forming cytotoxin that is produced by most S. aureus strains, can cause tissue injury and plays a critical role in the virulence of this pathoge...
作者:... Yan Liu , Xuming Deng , Liping Peng
来源:[J].World Journal of Microbiology and Biotechnology(IF 1.262), 2015, Vol.31 (8), pp.1259-1265Springer
摘要:Abstract(#br)Methicillin-resistant Staphylococcus aureus (MRSA) has become increasingly important because it is the most common cause of hospital-acquired infections, which have become globally epidemic. Our study specifically focused on the MRSA strain USA300, which was sho...

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