Diagnosis Press期刊
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作者:Rumena Petkova , Hemanth Tummala , Nikolai Zhelev
来源:[J].Biotechnology & Biotechnological Equipment(IF 0.622), 2011, Vol.25 (4), pp.2572-2575Diagnosis Press
摘要:High-mobility group A (HMGA) proteins are major transcription regulators which are abundantly and ubiquitously expressed in undifferentiated cells but present at a low level in somatic cells of adult organisms. Up-regulation of HMGA expression is a frequent finding in cancer, eit...
作者:Rumena Petkova , Zlatina Chicheva , Stoyan Chakarov
来源:[J].Biotechnology & Biotechnological Equipment(IF 0.622), 2011, Vol.25 (4), pp.2576-2582Diagnosis Press
摘要:Telomeres are ribonucleoproteid complexes capping the ends of linear genomes and protecting them from attrition and fusion. The rate of telomere shortening is related to cellular aging and a loss of telomere length is observed in a significant proportion of human diseases an...
作者:Rumena Petkova , Iliya Tsekov ...
来源:[J].Biotechnology & Biotechnological Equipment(IF 0.622), 2012, Vol.26 (1), pp.2689-2694Diagnosis Press
摘要:The rate of infection with human papillomavirus (HPV) worldwide is about 80% of the adult population. Anogenital HPV infections are usually transient and cause no lasting damage. In about 15-20% of the cases, however, the HPV infection may persist and in about 1% it may cause tra...
作者:Rumena Petkova , Pavlina Chelenkova ...
来源:[J].Biotechnology & Biotechnological Equipment(IF 0.622), 2013, Vol.27 (6), pp.4208-4216Diagnosis Press
摘要:The capacity for repair of damage in DNA may vary between clinically healthy people and in patients with different diseases and conditions, contributing to the risk for development of late-onset multifactorial disease, eligibility for different therapies and various therapy-relat...
作者:Rumena Petkova , Pavlina Chelenkova ...
来源:[J].Biotechnology & Biotechnological Equipment(IF 0.622), 2013, Vol.27 (6), pp.4217-4221Diagnosis Press
摘要:HPV infection is a major pathogenetic factor in cervical carcinoma as well as in many of the squamous cancers of head and neck and other epithelial cancers. Persistence of HPV DNA detectable by routine methods is considered to be a risk factor for advanced CIN and, in patients tr...
作者:Rumena Petkova , Stoimen Yochev ...
来源:[J].Biotechnology & Biotechnological Equipment(IF 0.622), 2011, Vol.25 (4), pp.2639-2641Diagnosis Press
摘要:Brown trout (Salmo trutta fario) is a popular object of recreational fishing in Bulgaria and throughout Europe. Free-living (‘wild’) populations of brown trout are seen in many cold water rivers, and restocking of artificial as well natural water basins is carried out routin...
作者:Stoyan Chakarov , Rumena Petkova , George Ch. Russev
来源:[J].Biotechnology & Biotechnological Equipment(IF 0.622), 2012, Vol.26 (1), pp.2695-2702Diagnosis Press
摘要:p53 is a master regulator of the cell cycle, capable of assessing the severity and the scope of damage to the cellular DNA, integrating the signals from the cell under stress and delivering the final decision about the destiny of the cell – undertaking repair activities; ent...
作者:Hilal S. Khalil , Rumena Petkova , Nikolai Zhelev
来源:[J].Biotechnology & Biotechnological Equipment(IF 0.622), 2012, Vol.26 (1), pp.2703-2711Diagnosis Press
摘要:Human society ages at a steady rate, that is, the proportion of adult and elderly individuals increases constantly because of improved living conditions and the advances in medical care. This means that very soon the tradeoff between the advantages in old age conferred by alleles...
作者:... Pavlina Chelenkova , Rumena Petkova , Stoyan Chakarov
来源:[J].Biotechnology & Biotechnological Equipment(IF 0.622), 2012, Vol.26 (4), pp.3142-3147Diagnosis Press
摘要:The DNA repair machinery of healthy human cells usually manages the consequences of the daily barrage of DNA damage for years and decades before any adverse effects related to genotoxic impact become manifest. There is significant variance, however, even between healthy individua...
作者:Rumena Petkova , Stoimen Yochev ...
来源:[J].Biotechnology & Biotechnological Equipment(IF 0.622), 2012, Vol.26 (2), pp.2894-2898Diagnosis Press
摘要:Human impact on genetic variability of species is a prominent cause for loss of biodiversity on a global scale. The present work offers evidence that the genetic diversity in Bulgarian native populations of brown trout is already failing because of alteration of the population st...

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