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作者:Han S. J. Cheong , Mark F. A. VanBerkum
来源:[J].PLOS ONE(IF 3.73), 2017, Vol.12 (12)PLOS
摘要:Abelson tyrosine kinase (Abl) is a key regulator of actin-related morphogenetic processes including axon guidance, where it functions downstream of several guidance receptors. While the long C-terminal domain (CTD) of Abl is required for function, its role is poorly understood. H...
作者:... Stephanie Karmo , Mark A. Seeger , Mark F. A. VanBerkum
来源:[J].PLOS ONE(IF 3.73), 2010, Vol.5 (3)PLOS
摘要:In the Drosophila embryonic nerve cord, the formation of commissures require both the chemoattractive Netrin receptor Frazzled (Fra) and the Abelson (Abl) cytoplasmic tyrosine kinase. Abl binds to the cytoplasmic domain of Fra and loss-of-function mutations in abl enhance fra -de...

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