Wolters Kluwer期刊
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作者:Laura Cavalleri , Cristiano Chiamulera
来源:[J].NeuroReport(IF 1.404), 2018Wolters Kluwer
摘要:The mechanisms underlying the prolonged antidepressant effects after a single exposure to ketamine are only partially understood. Converging findings indicate a critical role of structural neuroplasticity, recently also proposed for dopaminergic (DA) neurons known to be invo...
作者:Laura Cavalleri , Cristiano Chiamulera
来源:[J].NeuroReport(IF 1.404), 2018Wolters Kluwer
摘要:The mechanisms underlying the prolonged antidepressant effects after a single infusion of ketamine are only partially understood. Ketamine’s half-life of ∼2 h cannot explain antidepressant effects that last for 1 week, suggesting the triggering of long-lasting neuroplasticit...
作者:Laura Cavalleri , Marco Venniro ...
来源:[J].NeuroReport(IF 1.404), 2018Wolters Kluwer
摘要:Ketamine is a noncompetitive glutamate N-methyl-D-aspartic acid receptor antagonist. When acutely administered to rodents, it produces a rapid antidepressant effect. There is evidence that N-methyl-D-aspartic acid receptor blockade enhances glutamatergic transmission prefere...

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