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作者:Kazuaki Taguchi , Koji Nishi ...
来源:[J].PLOS ONE(IF 3.73), 2017, Vol.12 (6)PLOS
摘要:A wide variety of drugs bind to human serum albumin (HSA) at its two principal sites, namely site I and site II. A number of reports indicate that drug binding to these two binding sites are not completely independent, and that interactions between ligands of these two discr...
作者:Kazuaki Taguchi , Takako Ishiguro ...
来源:[J].PLOS ONE(IF 3.73), 2018, Vol.13 (6)PLOS
摘要:4′-cyano-2′-deoxyinosine (SK14-061a), a novel nucleoside analog based on inosine, has antiviral activity against the human immunodeficiency virus type 1 that has the ability to acquire resistance against many types of reverse transcriptase inhibitors based on nucleosides. Th...
作者:Kazuaki Taguchi , Saori Nagao ...
来源:[J].PLOS ONE(IF 3.73), 2016, Vol.11 (2)PLOS
摘要:A hemoglobin wrapped covalently by three human serum albumins, a Hb-HSA 3 cluster, is an artificial O2-carrier with the potential to function as a red blood cell substitute. This paper describes the synthesis and O2-binding properties of new...
作者:Kazuaki Taguchi , Keishi Yamasaki ...
来源:[J].PLOS ONE(IF 3.73), 2016, Vol.11 (10)PLOS
摘要:Hemoglobin-vesicles (HbV), encapsulating highly concentrated human hemoglobin in liposomes, were developed as a substitute for red blood cells (RBC) and their safety and efficacy in transfusion therapy has been confirmed in previous studies. Although HbV suspensions are structura...

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