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作者:Hiroyuki Nakamura , Yutaka Kobayashi ...
来源:[J].PLOS ONE(IF 3.73), 2018, Vol.13 (3)PLOS
摘要:Although several studies have demonstrated a potential correlation of dietary patterns with cognitive function, the relationship between tooth loss and dietary patterns and cognitive function have not been identified. In this cross-sectional study, we used a reduced rank reg...
作者:... Kiyonobu Komai , Hiroyuki Nakamura , Masahito Yamada
来源:[J].PLOS ONE(IF 3.73), 2014, Vol.9 (5)PLOS
摘要:Our objective was to determine whether the consumption of green tea, coffee, or black tea influences the incidence of dementia and mild cognitive impairment (MCI) in older people. We conducted a population-based prospective study with Japanese residents aged >60 years from N...
作者:... Shoko Kobayashi , Hiroyuki Nakamura , Masahito Yamada
来源:[J].PLOS ONE(IF 3.73), 2015, Vol.10 (5)PLOS
摘要:The aim of this study was to evaluate the safety, tolerability and pharmacokinetics of single dose of Melissa officinalis extract which contained rosmarinic acid, including food-effects in healthy individuals. A total of eleven healthy individuals were randomly assigned to t...
作者:Hiroyuki Nakamura , Hideaki Nagase ...
来源:[J].PLOS ONE(IF 3.73), 2016, Vol.11 (12)PLOS
摘要:Bone development and length relies on the growth plate formation, which is dependent on degradative enzymes such as MMPs. Indeed, deletion of specific members of this enzyme family in mice results in important joint and bone abnormalities, suggesting a role in skeletal developmen...
作者:Hiroyuki Nakamura , Masa-aki Kawashiri
来源:[J].PLOS ONE(IF 3.73), 2014, Vol.9 (7)PLOS
摘要:Myocardial scarring can be assessed by cardiac magnetic resonance imaging with late gadolinium enhancement and by endomyocardial biopsy. However, accuracy of late gadolinium enhancement for predicting microscopic myocardial scarring in biopsied specimens remains unknown in h...
作者:... Tamotsu Ishizuka , Tamehito Onoe , Hiroyuki Nakamura
来源:[J].PLOS ONE(IF 3.73), 2015, Vol.10 (9)PLOS
摘要:The high heritability of plasma renin activity was confirmed in recent investigations. A variation located near the strong enhancer of the human renin gene ( REN ), C-5312T, has been shown to have different transcription activity levels depending on its allele: the 5312T all...
作者:Hiroyuki Nakamura , Yukio Kawagishi ...
来源:[J].PLOS ONE(IF 3.73), 2016, Vol.11 (3)PLOS
摘要:A positive association between the number of cigarettes smoked per day and obesity has been reported, whereas how other smoking-related indices, such as pack-years and duration of smoking, are related with obesity has been less investigated. We analyzed the age-adjusted cros...
作者:Hiroyuki Nakamura , Hirotoshi Matsui ...
来源:[J].PLoS ONE(IF 3.73), 2016, Vol.11 (4)PLOS
摘要:The QuantiFERON®-TB Gold In-Tube test (QFT), an interferon-γ release assay, is used to diagnose Mycobacterium tuberculosis , but its inaccuracy in distinguishing active tuberculosis from latent infection is a major concern. There is thus a need for an easy and accurate tool ...
作者:... Hiroshi Nakamura , Hiroyuki Nakamura , Misako Nakashima
来源:[J].PLOS ONE(IF 3.73), 2012, Vol.7 (12)PLOS
摘要:Matrix metalloproteinases (MMPs) are involved in extracellular matrix degradation and the modulation of cell behavior. These proteinases have also been implicated in tissue repair and regeneration. Our previous studies have demonstrated that MMP-3 elicits stimulatory effects on t...
作者:Hiroyuki Nakamura , Mamoru Ito ...
来源:[J].PLOS Pathogens(IF 9.127), 2011, Vol.7 (10)PLOS
摘要:Epstein-Barr virus (EBV), a ubiquitous B-lymphotropic herpesvirus, ectopically infects T or NK cells to cause severe diseases of unknown pathogenesis, including chronic active EBV infection (CAEBV) and EBV-associated hemophagocytic lymphohistiocytosis (EBV-HLH). We developed...

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