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作者:Guang Xu , David H. Walker ...
来源:[J].PLOS Neglected Tropical Diseases(IF 4.569), 2017, Vol.11 (11)PLOS
摘要:Scrub typhus is a serious public health problem in the Asia-Pacific area. It threatens one billion people globally, and causes illness in one million people each year. Caused by Orientia tsutsugamushi , scrub typhus can result in severe multiorgan failure with a case fatality rat...
作者:Guang Xu , Nicole L. Mendell ...
来源:[J].PLOS Neglected Tropical Diseases(IF 4.569), 2017, Vol.11 (7)PLOS
摘要:Scrub typhus, caused by a Gram-negative obligately intracellular coccobacillus, Orientia tsutsugamushi , is a long neglected but important tropical disease. Orientia tsutsugamushi causes illness in one million people each year, and 1 billion people are at risk. Without appro...
作者:Guang Xu , Haitao Hu ...
来源:[J].PLOS Neglected Tropical Diseases(IF 4.716), 2016, Vol.10 (3)PLOS
摘要:Endothelial cells (EC) are the main target for Orientia tsutsugamushi infection and EC dysfunction is a hallmark of severe scrub typhus in patients. However, the molecular basis of EC dysfunction and its impact on infection outcome are poorly understood. We found that C57BL/6 mic...
作者:Guang Xu , Yenny Goez-Rivillas ...
来源:[J].PLOS Neglected Tropical Diseases(IF 4.716), 2016, Vol.10 (8)PLOS
摘要:Scrub typhus is a neglected tropical disease, caused by Orientia tsutsugamushi , a Gram-negative bacterium that is transmitted to mammalian hosts during feeding by Leptotrombidium mites and replicates predominantly within endothelial cells. Most studies of scrub typhus in an...
作者:Guang Xu , Lynn Soong ...
来源:[J].PLOS Neglected Tropical Diseases(IF 4.716), 2014, Vol.8 (7)PLOS
摘要:Orientia tsutsugamushi , the etiologic agent of scrub typhus, is a mite-borne rickettsia transmitted by the parasitic larval stage of trombiculid mites. Approximately one-third of the world's population is at risk of infection with Orientia tsutsugamushi , emphasizing its im...
作者:Guang Xu , Juan Xie ...
来源:[J].PLOS ONE(IF 3.73), 2014, Vol.9 (2)PLOS
摘要:Transperineal ultrasound-guided (TPUS) 12-core prostate biopsy was evaluated as an initial strategy for the diagnosis of prostate cancer, The distribution of prostate cancer lesions was assessed with zone-specific biopsy.;;From January 2010 to December 2012, 287 patients underwen...

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