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作者:Diane P. Genereux , Jamie Goodson ...
来源:[J].PLOS Genetics(IF 8.694), 2017, Vol.13 (11)PLOS
摘要:In storing and transmitting epigenetic information, organisms must balance the need to maintain information about past conditions with the capacity to respond to information in their current and future environments. Some of this information is encoded by DNA methylation, which ca...
作者:Diane P. Genereux , Alessandro Guffanti ...
来源:[J].PLOS ONE(IF 3.73), 2013, Vol.8 (7)PLOS
摘要:The survival of a species depends on its capacity to adjust to changing environmental conditions, and new stressors. Such new, anthropogenic stressors include the neonicotinoid class of crop-protecting agents, which have been implicated in the population declines of pollinat...
作者:Diane P. Genereux , Reinhard Stöger ...
来源:[J].PLOS ONE(IF 3.73), 2012, Vol.7 (3)PLOS
摘要:DNA methyltransferases establish methylation patterns in cells and transmit these patterns over cell generations, thereby influencing each cell's epigenetic states. Three primary DNA methyltransferases have been identified in mammals: DNMT1, DNMT3A and DNMT3B. Extensive in vitro ...
作者:Diane P. Genereux , Randi J. Hagerman ...
来源:[J].PLOS ONE(IF 3.73), 2011, Vol.6 (8)PLOS
摘要:Variability among individuals in the severity of fragile X syndrome (FXS) is influenced by epigenetic methylation mosaicism, which may also be common in other complex disorders. The epigenetic signal of dense promoter DNA methylation is usually associated with gene silencing, as ...
作者:Diane P. Genereux
来源:[J].PLOS Genetics(IF 8.694), 2009, Vol.5 (6)PLOS
摘要:Asymmetric strand segregation has been proposed as a mechanism to minimize effective mutation rates in epithelial tissues. Under asymmetric strand segregation, the double-stranded molecule that contains the oldest DNA strand is preferentially targeted to the somatic stem cel...

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