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作者:David H. Walker , Daniel Jupiter ...
来源:[J].PLOS Neglected Tropical Diseases(IF 4.569), 2017, Vol.11 (11)PLOS
摘要:Scrub typhus is a serious public health problem in the Asia-Pacific area. It threatens one billion people globally, and causes illness in one million people each year. Caused by Orientia tsutsugamushi , scrub typhus can result in severe multiorgan failure with a case fatality rat...
作者:... Lynn Soong , Donald H. Bouyer , David H. Walker
来源:[J].PLOS Neglected Tropical Diseases(IF 4.569), 2017, Vol.11 (7)PLOS
摘要:Scrub typhus, caused by a Gram-negative obligately intracellular coccobacillus, Orientia tsutsugamushi , is a long neglected but important tropical disease. Orientia tsutsugamushi causes illness in one million people each year, and 1 billion people are at risk. Without appro...
作者:... Gustavo Valbuena , David H. Walker , Donald H. Bouyer
来源:[J].PLOS Neglected Tropical Diseases(IF 4.716), 2016, Vol.10 (8)PLOS
摘要:Scrub typhus is a neglected tropical disease, caused by Orientia tsutsugamushi , a Gram-negative bacterium that is transmitted to mammalian hosts during feeding by Leptotrombidium mites and replicates predominantly within endothelial cells. Most studies of scrub typhus in an...
作者:... Nahed Ismail , David H. Walker , Rong Fang
来源:[J].PLOS ONE(IF 3.73), 2016, Vol.11 (6)PLOS
摘要:Rickettsiae actively escape from vacuoles and replicate free in the cytoplasm of host cells, where inflammasomes survey the invading pathogens. In the present study, we investigated the interactions of Rickettsia australis with the inflammasome in both mouse and human macrop...
作者:... Lynn Soong , Rong Fang , David H. Walker
来源:[J].PLOS ONE(IF 3.73), 2012, Vol.7 (3)PLOS
摘要:Due to its strong immune stimulatory effects through TLR9, CpG-containing oligodeoxynucleotides (CpG ODN) have been tested in multiple clinical trials as vaccine adjuvant for infectious diseases and cancer. However, immune suppression induced by systemic administration of Cp...
作者:... Casey L. C. Schroeder , David H. Walker , Sanjeev K. Sahni
来源:[J].PLOS ONE(IF 3.73), 2017, Vol.12 (8)PLOS
摘要:Rickettsial infections continue to cause serious morbidity and mortality in severe human cases around the world. Host cell adhesion and invasion is an essential requisite for intracellular growth, replication, and subsequent dissemination of pathogenic rickettsiae. Heparan s...
作者:Nicole L. Mendell , Donald H. Bouyer , David H. Walker
来源:[J].PLOS Neglected Tropical Diseases(IF 4.716), 2017, Vol.11 (3)PLOS
摘要:Scrub typhus, a febrile illness of substantial incidence and mortality, is caused by infection with the obligately intracellular bacterium Orientia tsutsugamushi . It is estimated that there are more than one million cases annually transmitted by the parasitic larval stage o...
作者:... Gustavo Valbuena , Donald H. Bouyer , David H. Walker
来源:[J].PLOS Neglected Tropical Diseases(IF 4.716), 2014, Vol.8 (7)PLOS
摘要:Orientia tsutsugamushi , the etiologic agent of scrub typhus, is a mite-borne rickettsia transmitted by the parasitic larval stage of trombiculid mites. Approximately one-third of the world's population is at risk of infection with Orientia tsutsugamushi , emphasizing its im...
作者:... Gustavo A. Valbuena , Donald H. Bouyer , David H. Walker
来源:[J].PLOS Neglected Tropical Diseases(IF 4.716), 2014, Vol.8 (9)PLOS
摘要:Scrub typhus is a neglected, but important, tropical disease, which puts one-third of the world's population at risk. The disease is caused by Orientia tsutsugamushi , an obligately intracellular Gram-negative bacterium. Dysregulation in immune responses is known to contribu...
作者:... Natacha Milhano , David H. Walker , Rong Fang
来源:[J].PLOS ONE(IF 3.73), 2015, Vol.10 (9)PLOS
摘要:Rickettsiae primarily target microvascular endothelial cells. However, it remains elusive how endothelial cell responses to rickettsiae play a role in the pathogenesis of rickettsial diseases. In the present study, we employed two rickettsial species with high sequence homol...

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