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作者:Andrew J. Massey
来源:[J].PLOS ONE(IF 3.73), 2018, Vol.13 (4)PLOS
摘要:Determining and understanding drug target engagement is critical for drug discovery. This can be challenging within living cells as selective readouts are often unavailable. Here we describe a novel method for measuring target engagement in living cells based on the principle of ...
作者:Andrew J. Massey
来源:[J].PLOS ONE(IF 3.73), 2015, Vol.10 (7)PLOS
摘要:High-content imaging is a powerful tool for determining cell phenotypes at the single cell level. Characterising the effect of small molecules on cell cycle distribution is important for understanding their mechanism of action especially in oncology drug discovery but also f...
作者:Andrew J. Massey , Jenifer Borgognoni ...
来源:[J].PLOS ONE(IF 3.73), 2010, Vol.5 (10)PLOS
摘要:Checkpoint kinase 1 and 2 (Chk1/Chk2), and the Aurora kinases play a critical role in the activation of the DNA damage response and mitotic spindle checkpoints. We have identified a novel inhibitor of these kinases and utilized this molecule to probe the functional interplay betw...

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