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作者:Andreas H. Groll , Silke Gastine
来源:[B].Elsevier Inc.2020Elsevier
摘要:Invasive fungal infections are important causes of morbidity and mortality in critically ill and immunocompromised patients. Since these infections remain difficult to diagnose and can be rapidly fatal, appropriate antifungal therapy is key to successful prevention, management, a...
作者:Andreas H. Groll , Thomas J. Walsh
来源:[B].Elsevier Inc.2008Elsevier
摘要:Publisher Summary This chapter discusses the results of studies on antifungal drugs. Pulse-dose terbinafine has been compared with standard continuous-dose terbinafine for toenail onychomycosis in a double-blind, randomized, single-center, noninferiority study in 306 volunte...
作者:Andreas H. Groll , Thomas J. Walsh
来源:[B].Elsevier Inc.2002Elsevier
摘要:Publisher Summary This chapter discusses several antifungal drugs and their side effects. Impairment of taste has been reported in association with terbinafine and is believed to be associated with taste receptor dysfunction through inhibition of CYP450-dependent enzymes. Amphote...
作者:Andreas H. Groll , Thomas J. Walsh
来源:[B].Elsevier Inc.2003Elsevier
摘要:Publisher Summary This chapter discusses several antifungal drugs and their side effects. Amphotericin remains one of the most important agents for the management of invasive mycoses. Compared with conventional amphotericin B deoxycholate, lipid-based formulations (amphotericin B...
作者:Andreas H. Groll , Hedwig Kolve , Thomas J. Walsh
来源:[B].Elsevier Inc.2005Elsevier
摘要:Publisher Summary This chapter provides an overview of adverse effects of antifungal drugs. Liver minor abnormalities in liver function tests have been observed in up to 4% of patients taking oral terbinafine; however, several cases of more severe symptomatic reactions have ...
作者:Andreas H. Groll , Thomas J. Walsh
来源:[B].Elsevier Inc.2007Elsevier
摘要:Publisher Summary This chapter describes the different aspects of antifungal drugs. The susceptibility factors and drug interaction of allylamines and amphotericin are reviewed. In a multicenter, randomized, double-blind, parallel-group study, 63 patients aged 14–85 years wi...
作者:Andreas H. Groll , Christine Chiou , Thomas J. Walsh
来源:[B].Elsevier Inc.2001Elsevier
摘要:Publisher Summary This chapter presents the effects of allylamines, such as terbinafine, on the hematologic system and skin. The associated risk factors are discussed. Granulocytopenia is a rare adverse effect of terbinafine. In this regard, various case-studies are presente...

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