新英格兰医学期刊
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作者:Modi Shanu , Saura Cristina , Yamashita Toshinari ...
来源:[J].New England Journal of Medicine(IF 51.658), 2020, Vol.382 (7), pp.610-621
摘要:Background Trastuzumab deruxtecan (DS-8201 is an antibody-drug conjugate composed of an anti-HER2 (human epidermal growth factor receptor 2 antibody, a cleavable tetrapeptide-based linker, and a cytotoxic topoisomerase I inhibitor. In a phase 1 dose-finding study, a majority of t...
作者:De Backer Ole , Dangas George D. , Jilaihawi Hasan ...
来源:[J].New England Journal of Medicine(IF 51.658), 2020, Vol.382 (2), pp.130-139
摘要:Background Subclinical leaflet thickening and reduced leaflet motion of bioprosthetic aortic valves have been documented by four-dimensional computed tomography (CT. Whether anticoagulation can reduce these phenomena after transcatheter aortic-valve replacement (TAVR is not ...
作者:Dangas George D. , Tijssen Jan G.P. , Wöhrle Jochen ...
来源:[J].New England Journal of Medicine(IF 51.658), 2020, Vol.382 (2), pp.120-129
摘要:Background Whether the direct factor Xa inhibitor rivaroxaban can prevent thromboembolic events after transcatheter aortic-valve replacement (TAVR is unclear. Methods We randomly assigned 1644 patients without an established indication for oral anticoagulation after successful TA...
作者:Landrigan Philip J. , Frumkin Howard , Lundberg Brita E.
来源:[J].New England Journal of Medicine(IF 51.658), 2020, Vol.382 (2), pp.104-107
摘要:Natural gas has been hailed as a clean “transition” fuel — a bridge from the coal and oil of the past to the clean energy sources of the future. But gas is associated with health hazards and reduced social welfare and poses grave dangers to the global climate.
作者:Murthy Rashmi K. , Loi Sherene , Okines Alicia ...
来源:[J].New England Journal of Medicine(IF 51.658), 2020, Vol.382 (7), pp.597-609
摘要:Background Patients with human epidermal growth factor receptor 2 (HER2–positive metastatic breast cancer who have disease progression after therapy with multiple HER2-targeted agents have limited treatment options. Tucatinib is an investigational, oral, highly selective inh...
来源:[J].New England Journal of Medicine(IF 51.658), 2020, Vol.382 (12), pp.1185-1186
摘要:To the Editor: According to national surveys regarding the prevalence of tuberculosis during the past 15 years,1 the prevalence is two to three times as high as the previous estimates, a finding that reflects the large burden of undiagnosed tuberculosis. Community...
作者:Kerry L. Reynolds , Ryan J. Sullivan , Florian J. Fintelmann ...
来源:[J].New England Journal of Medicine(IF 51.658), 2020, Vol.382 (12), pp.1150-1159
摘要:A 64-year-old man with a history of melanoma presented to the hospital after evaluation for clumsiness of the right arm had revealed a brain mass. Metastatic melanoma was diagnosed, and treatment included combination immune checkpoint inhibitor therapy. Fevers, dyspnea, and cough...
作者:Lirong Zou , Feng Ruan , Mingxing Huang ...
来源:[J].New England Journal of Medicine(IF 51.658), 2020, Vol.382 (12), pp.1177-1179
摘要:The authors report results of an analysis of nasal and throat swabs from 17 patients in Zhuhai, China, who had received a diagnosis of Covid-19. Higher viral loads soon after symptom onset indicate the need for isolation strategies different from those used for the earlier SARS e...
作者:Eric J. Rubin , Lindsey R. Baden , Stephen Morrissey
来源:[J].New England Journal of Medicine(IF 51.658), 2020, Vol.382 (12)
摘要:In this audio interview conducted on March 18, 2020, the editors look beyond supportive care to evaluate possible treatments for the disease.
作者:Andrew J. Schoenfeld , James D. Kang
来源:[J].New England Journal of Medicine(IF 51.658), 2020, Vol.382 (12), pp.1161-1162
摘要:Lumbar disk herniations are among the most frequent causes of sciatica.1,2 Fortunately for patients, sciatica is generally self-limited and resolves within 3 months in 70 to 90% of patients.2 When symptoms do not improve, surgical diskectomy has been an acce...

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