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作者:John S. Cashman , Gyles E. Cozier , Charlotte Harrison ...
来源:[J].Biochemical Journal(IF 4.654), 2019, Vol.476 (22), pp.3505-3520波特兰出版社
摘要:The mosquitoes of the Anopheles and Aedes genus are some of the most deadly insects to humans because of their effectiveness as vectors of malaria and a range of arboviruses, including yellow fever, dengue, chikungunya, West Nile and Zika. The use of insecticides from different c...
作者:Joji Kusuyama , Kenjiro Bandow , Tomokazu Ohnishi ...
来源:[J].Biochemical Journal(IF 4.654), 2019, Vol.476 (22), pp.3533-3548波特兰出版社
摘要:Hypoxia in adipose tissue is regarded as a trigger that induces dysregulation of the secretory profile in adipocytes. Similarly, local dysregulation of adipocytokine secretion is an initial event in the deleterious effects of obesity on metabolism. We previously reported tha...
作者:Marta Sidoryk-Węgrzynowicz , Lidia Strużyńska
来源:[J].Biochemical Journal(IF 4.654), 2019, Vol.476 (22), pp.3493-3504波特兰出版社
摘要:Astrocytes, by maintaining an optimal environment for neuronal function, play a critical role in proper function of mammalian nervous system. They regulate synaptic transmission and plasticity and protect neurons against toxic insults. Astrocytes and neurons interact actively via...
作者:Eric Soubeyrand , Megan Kelly , Shea A. Keene ...
来源:[J].Biochemical Journal(IF 4.654), 2019, Vol.476 (22), pp.3521-3532波特兰出版社
摘要:Plants have evolved the ability to derive the benzenoid moiety of the respiratory cofactor and antioxidant, ubiquinone (coenzyme Q), either from the β-oxidative metabolism of p -coumarate or from the peroxidative cleavage of kaempferol. Here, isotopic feeding assays, gene co...
作者:Robert D. Grinshpon , Suman Shrestha , James Titus-McQuillan ...
来源:[J].Biochemical Journal(IF 4.654), 2019, Vol.476 (22), pp.3475-3492波特兰出版社
摘要:Apoptotic caspases evolved with metazoans more than 950 million years ago (MYA), and a series of gene duplications resulted in two subfamilies consisting of initiator and effector caspases. The effector caspase genes (caspases-3, -6, and -7) were subsequently fixed into the Chord...
作者:Asma U. Husna , Nancy Wang , Jonathan J. Wilksch ...
来源:[J].Biochemical Journal(IF 4.654), 2019, Vol.476 (22), pp.3435-3453波特兰出版社
摘要:Key physiological differences between bacterial and mammalian metabolism provide opportunities for the development of novel antimicrobials. We examined the role of the multifunctional enzyme S-adenosylhomocysteine/Methylthioadenosine (SAH/MTA) nucleosidase (Pfs) in the virul...
作者:Karen Strack , Natalia Lauri , Sabina María Maté ...
来源:[J].Biochemical Journal(IF 4.654), 2019, Vol.476 (22), pp.3455-3473波特兰出版社
摘要:Alpha hemolysin (HlyA) is the major virulence factor of uropathogenic Escherichia coli (UPEC) strains. Once in circulation, a low concentration of the toxin induces an increase in intracellular calcium that activates calpains — which proteolyse cytoskeleton proteins — and al...
作者:Lukas Uhrik , Lixiao Wang , Lucia Haronikova ...
来源:[J].Biochemical Journal(IF 4.654), 2019, Vol.476 (21), pp.3401-3411波特兰出版社
摘要:Allosteric changes imposed by post-translational modifications regulate and differentiate the functions of proteins with intrinsic disorder regions. HDM2 is a hub protein with a large interactome and with different cellular functions. It is best known for its regulation of t...
作者:Amadeus Huang , Julia Burke , Richard D. Bunker ...
来源:[J].Biochemical Journal(IF 4.654), 2019, Vol.476 (21), pp.3369-3383波特兰出版社
摘要:4-hydroxy-2-oxoglutarate aldolase (HOGA1) is a mitochondrial enzyme that plays a gatekeeper role in hydroxyproline metabolism. Its loss of function in humans causes primary hyperoxaluria type 3 (PH3), a rare condition characterised by excessive production of oxalate. In this...
作者:Malti Yadav , Kamalendu Pal , Udayaditya Sen
来源:[J].Biochemical Journal(IF 4.654), 2019, Vol.476 (21), pp.3333-3353波特兰出版社
摘要:Cyclic dinucleotides (CDNs) have emerged as the central molecules that aid bacteria to adapt and thrive in changing environmental conditions. Therefore, tight regulation of intracellular CDN concentration by counteracting the action of dinucleotide cyclases and phosphodieste...

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