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作者:Chad R. Schultz , Caleb P. Bupp , Surender Rajasekaran ...
来源:[J].Biochemical Journal(IF 4.654), 2019, Vol.476 (14), pp.2047-2057波特兰出版社
摘要:We recently described a new autosomal dominant genetic disorder in a pediatric patient caused by a heterozygous de novo mutation in the ornithine decarboxylase 1 ( ODC1 ) gene. The new genetic disorder is characterized by global developmental delay, alopecia, overgrowth, and...
作者:Nélida Leiva Eriksson , Brandon J. Reeder , Michael T. Wilson ...
来源:[J].Biochemical Journal(IF 4.654), 2019, Vol.476 (14), pp.2111-2125波特兰出版社
摘要:In contrast with human hemoglobin (Hb) in red blood cells, plant Hbs do not transport oxygen, instead research points towards nitrogen metabolism. Using comprehensive and integrated biophysical methods we characterized three sugar beet Hbs: BvHb1.1, BvHb1.2 and BvHb2. Their ...
作者:Barbara Demmig-Adams , Jared J. Stewart , William W. Adams
来源:[J].Biochemical Journal(IF 4.654), 2019, Vol.476 (14), pp.2017-2029波特兰出版社
摘要:Antioxidant systems modulate oxidant-based signaling networks and excessive removal of oxidants can prevent beneficial acclimation responses. Evidence from mutant, transgenic, and locally adapted natural plant systems is used to interpret differences in the capacity for anti...
作者:Bing Liu , L. Maria Lois , David Reverter
来源:[J].Biochemical Journal(IF 4.654), 2019, Vol.476 (14), pp.2127-2139波特兰出版社
摘要:SUMOylation of proteins involves the concerted action of the E1-activating enzyme, E2-conjugating enzyme and E3-ligases. An essential discrimination step in the SUMOylation pathway corresponds to the initial interaction between E1 ubiquitin-fold domain (UFD) and E2 enzymes. ...
作者:Javier O. Cifuente , Natalia Comino , Beatriz Trastoy ...
来源:[J].Biochemical Journal(IF 4.654), 2019, Vol.476 (14), pp.2059-2092波特兰出版社
摘要:The evolution of metabolic pathways is a major force behind natural selection. In the spotlight of such process lies the structural evolution of the enzymatic machinery responsible for the central energy metabolism. Specifically, glycogen metabolism has emerged to allow orga...
作者:Lisa Merthan , Amelie Haller , Dietmar R. Thal ...
来源:[J].Biochemical Journal(IF 4.654), 2019, Vol.476 (14), pp.2093-2109波特兰出版社
摘要:One hallmark of Alzheimer's disease (AD) is the presence of amyloid plaques, which mainly consist of the amyloid precursor protein (APP) cleavage product amyloid β (Aβ). For cleavage to occur, the APP must be endocytosed from the cell surface. The phosphatidylinositol bindin...
作者:Christian Heinzle , Lara Mücke , Thomas Brune ...
来源:[J].Biochemical Journal(IF 4.654), 2019, Vol.476 (14), pp.2031-2046波特兰出版社
摘要:The endosomal sorting complex required for transport (ESCRT)-III is associated with a multitude of cellular processes involving membrane remodeling and abscission. The exact composition of ESCRT-III and the contribution of individual ESCRT-III family members to these diverse func...
作者:Rainer Kalscheuer , Ainhoa Palacios , Itxaso Anso ...
来源:[J].Biochemical Journal(IF 4.654), 2019, Vol.476 (14), pp.1995-2016波特兰出版社
摘要:Bacterial capsules have evolved to be at the forefront of the cell envelope, making them an essential element of bacterial biology. Efforts to understand the Mycobacterium tuberculosis (Mtb) capsule began more than 60 years ago, but the relatively recent development of mycob...
作者:Amelie Detterbeck , Manuela Nagel , Stefan Rensch ...
来源:[J].Biochemical Journal(IF 4.654), 2019, Vol.476 (13), pp.1889-1909波特兰出版社
摘要:Combating hidden hunger through molecular breeding of nutritionally enriched crops requires a better understanding of micronutrient accumulation. We studied natural variation in grain micronutrient accumulation in barley ( Hordeum vulgare L.) and searched for candidate genes...
作者:Shambhu Yadav , Bindia Chawla , Mohammad Anwar Khursheed ...
来源:[J].Biochemical Journal(IF 4.654), 2019, Vol.476 (13), pp.1857-1873波特兰出版社
摘要:Calcium signaling is essential for embryonic development but the signals upstream of calcium are only partially understood. Here, we investigate the role of the intracellular glutathione redox potential in calcium signaling using the Chac1 protein of zebrafish. A member of t...

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