智慧科学与技术公司
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作者:Janna Krueger , Felix Jules , Sadiye Reider ...
来源:[J].Receptors & Clinical Investigation, 2018, Vol.1智慧科学与技术公司
摘要:T-cell activation is mediated by a combination of signals from the antigen receptor (TCR) and co-receptors such as CD28, cytotoxic T-lymphocyte antigen-4 (CTLA-4), programmed cell death antigen 1 (PD-1), CD28H and others. Each is a member of the CD28 receptor gene family. CD28 se...
作者:Alison Xiaoqiao Xie , Angelo Chaia , Ken D. McCarthy
来源:[J].Receptors & Clinical Investigation, 2018, Vol.1智慧科学与技术公司
摘要:Gq G protein-coupled receptor (Gq-GPCR) signaling in glial fibrillary acidic protein-expressing (GFAP + ) glia is essential for neuron-glia interaction in the Central Nervous System (CNS). However, the exploration of the roles of Gq-GPCR signaling in peripheral GFAP + glia has ju...
作者:Rahul Dilip Chavan , Sanket Bapat , Vrushali Patil ...
来源:[J].Receptors & Clinical Investigation, 2018, Vol.1智慧科学与技术公司
摘要:Influenza viruses are major human pathogens accountable for respiratory diseases affecting millions of people worldwide and characterized by high morbidity and significant mortality. Influenza infections can be controlled by vaccination and antiviral drugs. However, vaccines...
作者:Hua She , Yingli He , Yingren Zhao ...
来源:[J].Macrophage, 2018, Vol.5智慧科学与技术公司
摘要:Autophagy and inflammation are two processes vital for immune cells to perform their functions. Their proper interplay upon signal is pivotal for proper response to stress. The stress kinase p38α MAPK in microglia senses inflammatory cue LPS, directly phosphorylates ULK1, re...
作者:Mami Ishikawa , Riho Mashiba , Kumpei Kawakatsu ...
来源:[J].Macrophage, 2018, Vol.5智慧科学与技术公司
摘要:Innate immunity is at the frontline of defense against pathogens. Macrophages are a group of phagocytes that secrete cytokines to mediate the transmission of information on pathogen infectiousness to the acquired immune system. Our previous study established an assay for quantify...
作者:Mrinal Kanti Ghosh , Bhaskar Basu , Gouranga Saha ...
来源:[J].Cancer Cell & Microenvironment, 2018, Vol.5 (1)智慧科学与技术公司
摘要:The ubiquitin specific protease USP7/HAUSP is a major deubiquitinase that acts upon a wide spectrum of substrate proteins. Deubiquitination by USP7 generally leads to stabilization of substrates and their rescue from proteasomal degradation, but can also lead to alteration in the...
作者:Hugo Rubén Arias , Dominik Feuerbachb , Marcelo Ortells
来源:[J].Neurotransmitter, 2018, Vol.5智慧科学与技术公司
摘要:The interaction of (±)-bupropion [(±)-BP] with the human (h) α3β4 nicotinic acetylcholine receptor (AChR) is determined by functional and structural approaches. The Ca 2+ influx results indicate that (±)-BP inhibits hα3β4 AChRs with ~2-fold lower potency than that for (...
作者:Abdolreza Esmaeilzadeh , Azita Mohammadzadeh , Nazila Bahmaie
来源:[J].Inflammation and Cell Signaling, 2018, Vol.5智慧科学与技术公司
摘要:Psoriasis is immune-mediated chronic inflammatory disorder related to Th1 pattern, in which, 2 to 3% of white population worldwide have been affected. It is demonstrated that excessive secretion of pro-inflammatory cytokines such as IL-17A, TNF-α, IL-6, IFN-γ, IL-2 and IL-12...
作者:Bridgette E. Drummond , Rebecca Ann Wingert
来源:[J].Cancer Cell & Microenvironment, 2018, Vol.5 (1)智慧科学与技术公司
摘要:Specialized renal epithelial cells known as podocytes are essential components of the filtering structures within the kidney that coordinate the process of removing waste from the bloodstream. Podocyte loss initiates many human kidney diseases as it triggers subsequent damag...
作者:Mei Shan Ong , Wanpei Cai , Tuan Zea Tan ...
来源:[J].RNA & DISEASE, 2018, Vol.5 (1)智慧科学与技术公司
摘要:Increasing number of reports have shown the involvement of LncRNAs in the tumour progression in multiple cancers including colorectal and female reproductive cancers such as ovarian and breast. In particular, the profiling of lncRNAs in colorectal cancer (CRC), which is within th...

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