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作者:Jixiang Liu , Haiyan Shi*
来源:[J].Advances in biology and medicine, 2018, Vol.2 (4)HCP
摘要:Cancer-associated fibroblast (CAF) is the main component of tumor microenvironment. The aim of this study was to investigate whether over-expression of matrix metalloproteinase 16 (MMP16) played a role in the pathologic progress of gastric cancer. Expression level of MMP16 was co...
作者:Xia Zhou , Ying Zhang , Chun Miu*
来源:[J].Advances in biology and medicine, 2018, Vol.2 (4)HCP
摘要:To investigate the diagnostic and prognostic value of EPX in endometrial cancer and its clinical significance. Methods A total number of 90 endometrial cancer tissues and the adjacent tissue were included in this study, and the expression of EPX in tumor tissues and the adja...
作者:Ting Luo , Yong Cao*
来源:[J].Advances in biology and medicine, 2018, Vol.2 (4)HCP
摘要:The aim of this study was to observe the effects of Baicalin on TGF-β1, α-SMA and NOX4 expression in renal tissues of rats with unilateral ureteral obstruction (UUO) and investigate the mechanism of it in renal interstitial fibrosis. The male Sprague-Dawley (SD) rats (27 rat...
作者:Zhen Li , Xiaofu Li , Yi Wang ...
来源:[J].Advances in biology and medicine, 2018, Vol.2 (4)HCP
摘要:The aim of this study is to investigate the role of miRNA-21-5p in the apoptosis of rat synovial cells induced by IL-1β. The synovial cells of rats were cultured in vitro and identification of type II collagen and proteoglycan were stained by toluidine blue method; The synov...
作者:Binghua Tang , Feng Yang , Yang Yang*
来源:[J].Advances in biology and medicine, 2018, Vol.2 (4)HCP
摘要:miR-630 was significantly up-regulated in cataract, however, the related mechanism remains unclear. The aim of this study was to examine the expression of miR-630 in cataract and the related mechanism. The expressions of miR-630 in the anterior lens capsules of patients with age-...
作者:Xiaoyu Zhang* , Ping Fan , Yan Yang
来源:[J].Advances in biology and medicine, 2017, Vol.2 (3)HCP
摘要:Objective: To investigate the expression of miR-22 in serum of patients with ovarian cancer and its diagnostic and prognostic values. Methods: Real-time quantitative PCR was performed to examine the expression of miR-22 in serum of 60 patients and 60 healthy volunteers. The chi-s...
作者:Lei Lei* , Bin Ye , Chunzhi Wu
来源:[J].Advances in biology and medicine, 2017, Vol.2 (3)HCP
摘要:Gastric cancer has become a common gastrointestinal malignancy. Previous studies have suggested that IL-37 was involved in the pathogenesis of different types of cancers; however, the roles of IL-37 in gastric cancer is unclear. The aim of this study is to explore the tumor suppr...
作者:Junsheng Wang* , Jie Li , Liexiang Zhang
来源:[J].Advances in biology and medicine, 2017, Vol.2 (3)HCP
摘要:To evaluate the protective effects of quercetin on renal injury of diabetic nephropathy (DN) rats based on renal function parameters and histopathological examinations (HE staining), and explore its possible mechanism by establishing DN rat models induced by high-sugar high-...
作者:Xianlei Chen , Liming Tao* , Yun Xu ...
来源:[J].Advances in biology and medicine, 2017, Vol.2 (3)HCP
摘要:The aim of this study is to explain the effect and mechanism of miRNA-200c in the diabetic retinopathy. The 27 mice were randomly divided into 3 groups: NC group, Model group and miRNA group. The mice of Model and miRNA groups were injected with STZ to prepare the diabetic m...
作者:Liqiong Huang , Bo Zheng* , Yi He
来源:[J].Advances in biology and medicine, 2017, Vol.2 (3)HCP
摘要:Accelerated apoptosis of granulosa cells is one of the causes influencing follicle atresia and contributes to the etiology of polycystic ovarian syndrome (PCOS). During our previous work, we found that miR-202 was up-regulated in dehydroandrosterone-induced rat PCOS model. T...

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