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Ketofol performance to reduce postoperative emergence agitation in children undergoing adenotonsillectomy.
作者：Ali Idress , Alahdal Murad , Xia Haifa ...
来源：[J].The Libyan journal of medicine, 2020, Vol.15 (1), pp.1688450PubMed
摘要：Background : Emergence agitation is a reformed state of mindfulness, which starts with a sudden form of anesthesia and progresses through the early repossession age. Thus, the purpose of this study is to evaluate 1:3 ketofol performance on children 3-15 years old undergoing adeno...
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    Discovery and evaluation of novel synthetic 5-alkyl-4-oxo-4,5-dihydro-[1,2,4]triazolo[4,3-a]quinoxaline-1-carbox-amide derivatives as anti-inflammatory agents.
    作者：Shen Qing-Kun , Gong Guo-Hua , Li Gao- ...
    来源：[J].Journal of enzyme inhibition and medicinal chemistry, 2020, Vol.35 (1), pp.85-95PubMed
    摘要：To develop novel anti-inflammatory agents, a series of 5-alkyl-4-oxo-4,5-dihydro-[1, 2, 4]triazolo[4,3-a]quinoxaline-1-carboxamide derivatives were designed, synthesised, and evaluated for anti-inflammatory effects using RAW264.7 cells. Structures of the synthesised compound...
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      Design and implementation of an academic enrichment program to improve performance on the internal medicine in-training exam.
      作者：Dokmak Amr , Radwan Amr , Halpin Meredith ...
      来源：[J].Medical education online, 2020, Vol.25 (1), pp.1686950PubMed
      摘要：The internal medicine In-Training Exam (ITE) is administered at residency training programs to assess medical knowledge. Our internal medicine residency program witnessed a performance decline on the ITE between 2011 and 2014. The goal of this quality improvement project was...
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        Synthesis and biological evaluation of novel thienopyrimidine derivatives as diacylglycerol acyltransferase 1 (DGAT-1) inhibitors.
        作者：Hong Dong Jin , Jung Seung Hyun , Kim Jisook ...
        来源：[J].Journal of enzyme inhibition and medicinal chemistry, 2020, Vol.35 (1), pp.227-234PubMed
        摘要：A novel series of thieno[3,2- d ]pyrimidine derivatives were synthesised and their inhibitory effects against diacylglycerol acyltransferase 1 (DGAT-1) were assessed. cis-Isomer 17a showed potent and selective inhibitory activity against DGAT-1 in SF9 cells. In addition, 17a had ...
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          Further validation of strecker-type α-aminonitriles as a new class of potent human carbonic anhydrase II inhibitors: hit expansion within the public domain using differential scanning fluorimetry leads to chemotype refinement.
          作者：Krasavin Mikhail , Kalinin Stanislav , Zozulya Sergey ...
          来源：[J].Journal of enzyme inhibition and medicinal chemistry, 2020, Vol.35 (1), pp.165-171PubMed
          摘要：Testing of an expanded, 800-compound set of analogues of the earlier described Strecker-type α-aminonitriles (selected from publicly available Enamine Ltd. Screening Collection) in thermal shift assay against bovine carbonic anhydrase ( b CA) led to further validation of thi...
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            Towards discovery of new leishmanicidal scaffolds able to inhibit Leishmania GSK-3.
            作者：Martínez de Iturrate Paula , Sebastián-Pérez Victor , Nácher-Vázquez Montserrat ...
            来源：[J].Journal of enzyme inhibition and medicinal chemistry, 2020, Vol.35 (1), pp.199-210PubMed
            摘要：Previous reports have validated the glycogen synthase kinase-3 (GSK-3) as a druggable target against the human protozoan parasite Leishmania . This prompted us to search for new leishmanicidal scaffolds as inhibitors of this enzyme from our in-house library of human GSK-3β i...
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              Discovery of talmapimod analogues as polypharmacological anti-inflammatory agents.
              作者：Liu Wandong , Hou Caiyun , Li Jiaming ...
              来源：[J].Journal of enzyme inhibition and medicinal chemistry, 2020, Vol.35 (1), pp.187-198PubMed
              摘要：Twenty novel talmapimod analogues were designed, synthesised and evaluated for the in vivo anti-inflammatory activities. Among them, compound 6n , the most potent one, was selected for exploring the mechanisms underlying its anti-inflammatory efficacy. In RAW264.7 cells, it ...
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                Identifying novel sphingosine kinase 1 inhibitors as therapeutics against breast cancer.
                作者：Khan Faez Iqbal , Lai Dakun , Anwer Razique ...
                来源：[J].Journal of enzyme inhibition and medicinal chemistry, 2020, Vol.35 (1), pp.172-186PubMed
                摘要：Sphingosine kinase 1 (SphK1) is a promising therapeutic target against several diseases including mammary cancer. The aim of present work is to identify a potent lead compound against breast cancer using ligand-based virtual screening, molecular docking, MD simulations, and ...
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                  Enzyme-assisted modification of flavonoids from Matricaria chamomilla : antioxidant activity and inhibitory effect on digestive enzymes.
                  作者：Franco Elida Paula Dini de , Contesini Fabiano Jares , Lima da Silva Bianca ...
                  来源：[J].Journal of enzyme inhibition and medicinal chemistry, 2020, Vol.35 (1), pp.42-49PubMed
                  摘要：Matricaria chamomilla L. contains antioxidant flavonoids that can have their bioactivity enhanced by enzymatic hydrolysis of specific glycosyl groups. This study implements an untargeted metabolomics approach based on ultra-performance liquid chromatography coupled with elec...
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                    Synthesis, biological evaluation, and molecular modelling of new naphthalene-chalcone derivatives as potential anticancer agents on MCF-7 breast cancer cells by targeting tubulin colchicine binding site.
                    作者：Wang Guangcheng , Liu Wenjing , Gong Zipeng ...
                    来源：[J].Journal of enzyme inhibition and medicinal chemistry, 2020, Vol.35 (1), pp.139-144PubMed
                    摘要：A series of naphthalene-chalcone derivatives ( 3a-3t ) were prepared and evaluated as tubulin polymerisation inhibitor for the treatment of breast cancer. All compounds were evaluated for their antiproliferative activity against MCF-7 cell line. The most of compounds display...
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