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作者:Ali Idress , Alahdal Murad , Xia Haifa ...
来源:[J].The Libyan journal of medicine, 2020, Vol.15 (1), pp.1688450PubMed
摘要:Background : Emergence agitation is a reformed state of mindfulness, which starts with a sudden form of anesthesia and progresses through the early repossession age. Thus, the purpose of this study is to evaluate 1:3 ketofol performance on children 3-15 years old undergoing adeno...
作者:Shen Qing-Kun , Gong Guo-Hua , Li Gao- ...
来源:[J].Journal of enzyme inhibition and medicinal chemistry, 2020, Vol.35 (1), pp.85-95PubMed
摘要:To develop novel anti-inflammatory agents, a series of 5-alkyl-4-oxo-4,5-dihydro-[1, 2, 4]triazolo[4,3-a]quinoxaline-1-carboxamide derivatives were designed, synthesised, and evaluated for anti-inflammatory effects using RAW264.7 cells. Structures of the synthesised compound...
作者:Dokmak Amr , Radwan Amr , Halpin Meredith ...
来源:[J].Medical education online, 2020, Vol.25 (1), pp.1686950PubMed
摘要:The internal medicine In-Training Exam (ITE) is administered at residency training programs to assess medical knowledge. Our internal medicine residency program witnessed a performance decline on the ITE between 2011 and 2014. The goal of this quality improvement project was...
作者:Hong Dong Jin , Jung Seung Hyun , Kim Jisook ...
来源:[J].Journal of enzyme inhibition and medicinal chemistry, 2020, Vol.35 (1), pp.227-234PubMed
摘要:A novel series of thieno[3,2- d ]pyrimidine derivatives were synthesised and their inhibitory effects against diacylglycerol acyltransferase 1 (DGAT-1) were assessed. cis-Isomer 17a showed potent and selective inhibitory activity against DGAT-1 in SF9 cells. In addition, 17a had ...
作者:Krasavin Mikhail , Kalinin Stanislav , Zozulya Sergey ...
来源:[J].Journal of enzyme inhibition and medicinal chemistry, 2020, Vol.35 (1), pp.165-171PubMed
摘要:Testing of an expanded, 800-compound set of analogues of the earlier described Strecker-type α-aminonitriles (selected from publicly available Enamine Ltd. Screening Collection) in thermal shift assay against bovine carbonic anhydrase ( b CA) led to further validation of thi...
作者:Martínez de Iturrate Paula , Sebastián-Pérez Victor , Nácher-Vázquez Montserrat ...
来源:[J].Journal of enzyme inhibition and medicinal chemistry, 2020, Vol.35 (1), pp.199-210PubMed
摘要:Previous reports have validated the glycogen synthase kinase-3 (GSK-3) as a druggable target against the human protozoan parasite Leishmania . This prompted us to search for new leishmanicidal scaffolds as inhibitors of this enzyme from our in-house library of human GSK-3β i...
作者:Liu Wandong , Hou Caiyun , Li Jiaming ...
来源:[J].Journal of enzyme inhibition and medicinal chemistry, 2020, Vol.35 (1), pp.187-198PubMed
摘要:Twenty novel talmapimod analogues were designed, synthesised and evaluated for the in vivo anti-inflammatory activities. Among them, compound 6n , the most potent one, was selected for exploring the mechanisms underlying its anti-inflammatory efficacy. In RAW264.7 cells, it ...
作者:Khan Faez Iqbal , Lai Dakun , Anwer Razique ...
来源:[J].Journal of enzyme inhibition and medicinal chemistry, 2020, Vol.35 (1), pp.172-186PubMed
摘要:Sphingosine kinase 1 (SphK1) is a promising therapeutic target against several diseases including mammary cancer. The aim of present work is to identify a potent lead compound against breast cancer using ligand-based virtual screening, molecular docking, MD simulations, and ...
作者:Franco Elida Paula Dini de , Contesini Fabiano Jares , Lima da Silva Bianca ...
来源:[J].Journal of enzyme inhibition and medicinal chemistry, 2020, Vol.35 (1), pp.42-49PubMed
摘要:Matricaria chamomilla L. contains antioxidant flavonoids that can have their bioactivity enhanced by enzymatic hydrolysis of specific glycosyl groups. This study implements an untargeted metabolomics approach based on ultra-performance liquid chromatography coupled with elec...
作者:Wang Guangcheng , Liu Wenjing , Gong Zipeng ...
来源:[J].Journal of enzyme inhibition and medicinal chemistry, 2020, Vol.35 (1), pp.139-144PubMed
摘要:A series of naphthalene-chalcone derivatives ( 3a-3t ) were prepared and evaluated as tubulin polymerisation inhibitor for the treatment of breast cancer. All compounds were evaluated for their antiproliferative activity against MCF-7 cell line. The most of compounds display...

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