牛津期刊
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作者:Ximing Du , Hongyuan Yang
来源:[J].Acta Biochim Biophys Sin(IF 1.807), 2013, Vol.45 (1), pp.11-17Oxford U Press
摘要:The delivery of low-density lipoprotein-derived cholesterol (LDL-C) from endosomal compartments to the plasma membrane and the endoplasmic reticulum (ER) is an important yet poorly understood cellular process. Niemann-Pick C1 (NPC1), a multi-pass integral membrane protein on the ...
作者:Weihua Wu , Shimin Zhao
来源:[J].Acta Biochim Biophys Sin(IF 1.807), 2013, Vol.45 (1), pp.18-26Oxford U Press
摘要:Altered metabolism is one of the hallmarks of cancer cells. The best-known metabolic abnormality in cancer cells is the Warburg effect, which demonstrates an increased glycolysis even in the presence of oxygen. However, tumor-related metabolic abnormalities are not limited to alt...
作者:Zhonghua Liu , Xun Huang
来源:[J].Acta Biochim Biophys Sin(IF 1.807), 2013, Vol.45 (1), pp.44-50Oxford U Press
摘要:Proteins, nucleic acids, and lipids are three major components of the cell. Despite a few basic metabolic pathways, we know very little about lipids, compared with the explosion of knowledge about proteins and nucleic acids. How many different forms of lipids are there? What are ...
作者:Songfang Wu , Huangying Le
来源:[J].Acta Biochim Biophys Sin(IF 1.807), 2013, Vol.45 (1), pp.27-35Oxford U Press
摘要:Cancer cells have distinct metabolism that highly depends on glycolysis instead of mitochondrial oxidative phosphorylation alone, known as aerobic glycolysis. Pyruvate kinase (PK), which catalyzes the final step of glycolysis, has emerged as a potential regulator of this metaboli...
作者:Tingting Zhang , Changhong Li
来源:[J].Acta Biochim Biophys Sin(IF 1.807), 2013, Vol.45 (1), pp.36-43Oxford U Press
摘要:The role of amino acids in the regulation of insulin secretion in pancreatic beta-cells is highlighted in three forms of congenital hyperinsulinism (HI), namely gain-of-function mutations of glutamate dehydrogenase (GDH), loss-of-function mutations of ATP-dependent potassium chan...
作者:Xiaoling Li
来源:[J].Acta Biochim Biophys Sin(IF 1.807), 2013, Vol.45 (1), pp.51-60Oxford U Press
摘要:Sirtuin 1 (SIRT1) is the most conserved mammalian NAD+-dependent protein deacetylase that has emerged as a key metabolic sensor in various metabolic tissues. In response to different environmental stimuli, SIRT1 directly links the cellular metabolic status to the chrom...
作者:Mi Shi , Xiangzhong Zheng
来源:[J].Acta Biochim Biophys Sin(IF 1.807), 2013, Vol.45 (1), pp.61-69Oxford U Press
摘要:An endogenous circadian (∼24 h) clock regulates rhythmic processes of physiology, metabolism and behavior in most living organisms. While able to free-run under constant conditions, the circadian clock is coupled to day : night cycles to increase its amplitude and align the ...
作者:Bao-Liang Song
来源:[J].Acta Biochim Biophys Sin(IF 1.807), 2013, Vol.45 (1), pp.1-1Oxford U Press
作者:Xu Xiao , Bao-Liang Song
来源:[J].Acta Biochim Biophys Sin(IF 1.807), 2013, Vol.45 (1), pp.2-10Oxford U Press
摘要:Sterol regulatory element-binding proteins (SREBPs) are major transcription factors regulating the biosynthesis of cholesterol, fatty acid, and triglyceride. They control the expression of crucial genes involved in lipogenesis and uptake. In this review, we summarize the processi...
作者:Ke Huang , Shiwu Dong , Wei Li ...
来源:[J].Acta Biochim Biophys Sin(IF 1.807), 2013, Vol.45 (10), pp.803-805Oxford U Press
摘要:Cancer is one of the leading causes of death worldwide. There is a definite need for novel approaches to improve the diagnostics and treatment of cancers. The pathological processes leading to carcinoma are associated with the altered expression of a specific gene relevant to mal...

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