牛津期刊
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作者:Wentao Kong , Venkata S. Kapuganti , Ting Lu
来源:[J].Nucleic Acids Research(IF 8.278), 2016, Vol.44 (4), pp.e37-e37Oxford U Press
摘要:Recent developments in synthetic biology have positioned lactic acid bacteria (LAB) as a major class of cellular chassis for applications. To achieve the full potential of LAB, one fundamental prerequisite is the capacity for rapid engineering of complex gene networks, such as na...
作者:Amanda A. Riccio , Gino Cingolani , John M. Pascal
来源:[J].Nucleic Acids Research(IF 8.278), 2016, Vol.44 (4), pp.1691-1702Oxford U Press
摘要:Poly(ADP-ribose) polymerase-2 (PARP-2) is one of three human PARP enzymes that are potently activated during the cellular DNA damage response (DDR). DDR-PARPs detect DNA strand breaks, leading to a dramatic increase in their catalytic production of the posttranslational modificat...
作者:Hsiao P.J. Voon , Lee H. Wong
来源:[J].Nucleic Acids Research(IF 8.278), 2016, Vol.44 (4), pp.1496-1501Oxford U Press
摘要:A number of studies have demonstrated that various components of the ATRX/DAXX/Histone H3.3 complex are important for heterochromatin silencing at multiple genomic regions. We provide an overview of the individual components (ATRX, DAXX and/or H3.3) tested in each study and propo...
作者:Tuval Ben Yehezkel , Arnaud Rival , Ofir Raz ...
来源:[J].Nucleic Acids Research(IF 8.278), 2016, Vol.44 (4), pp.e35-e35Oxford U Press
摘要:Microfluidics may revolutionize our ability to write synthetic DNA by addressing several fundamental limitations associated with generating novel genetic constructs. Here we report the first de novo synthesis and cell-free cloning of custom DNA libraries in sub-microliter reactio...
作者:Jyotsana J. Parmar , Dibyendu Das , Ranjith Padinhateeri
来源:[J].Nucleic Acids Research(IF 8.278), 2016, Vol.44 (4), pp.1630-1641Oxford U Press
摘要:It is being increasingly realized that nucleosome organization on DNA crucially regulates DNA–protein interactions and the resulting gene expression. While the spatial character of the nucleosome positioning on DNA has been experimentally and theoretically studied extensivel...
作者:Andrés López-Perrote , Raquel Castaño , Roberto Melero ...
来源:[J].Nucleic Acids Research(IF 8.278), 2016, Vol.44 (4), pp.1909-1923Oxford U Press
摘要:Nonsense-mediated mRNA decay (NMD) is an mRNA degradation pathway that regulates gene expression and mRNA quality. A complex network of macromolecular interactions regulates NMD initiation, which is only partially understood. According to prevailing models, NMD begins by the...
作者:Shiri Levy , Charles K. Allerston , Varda Liveanu ...
来源:[J].Nucleic Acids Research(IF 8.278), 2016, Vol.44 (4), pp.1813-1832Oxford U Press
摘要:Post-transcriptional control of mitochondrial gene expression, including the processing and generation of mature transcripts as well as their degradation, is a key regulatory step in gene expression in human mitochondria. Consequently, identification of the proteins responsi...
作者:Sai Zhang , Jingtian Zhou , Hailin Hu ...
来源:[J].Nucleic Acids Research(IF 8.278), 2016, Vol.44 (4), pp.e32-e32Oxford U Press
摘要:RNA-binding proteins (RBPs) play important roles in the post-transcriptional control of RNAs. Identifying RBP binding sites and characterizing RBP binding preferences are key steps toward understanding the basic mechanisms of the post-transcriptional gene regulation. Though numer...
作者:Takuya Kawamura , Akira Hirata , Satoshi Ohno ...
来源:[J].Nucleic Acids Research(IF 8.278), 2016, Vol.44 (4), pp.1894-1908Oxford U Press
摘要:Archaeosine (G+), which is found only at position 15 in many archaeal tRNA, is formed by two steps, the replacement of the guanine base with preQ0 by archaeosine tRNA-guanine transglycosylase (ArcTGT) and the subsequent modification of preQ0 to G<...
作者:Nandini Manickam , Kartikeya Joshi , Monika J. Bhatt ...
来源:[J].Nucleic Acids Research(IF 8.278), 2016, Vol.44 (4), pp.1871-1881Oxford U Press
摘要:Cellular health and growth requires protein synthesis to be both efficient to ensure sufficient production, and accurate to avoid producing defective or unstable proteins. The background of misreading error frequency by individual tRNAs is as low as 2 × 10−6 per c...

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