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作者:Olalla Montero-Pérez PharmD, María Beatriz Contreras-Rey PharmD, Ernesto Sánchez-Gómez PhD
来源:[J].Drugs in Context, 2019BioExcel出版社
摘要:Background: Asthma is an inflammatory disease of the airways with symptoms that vary over time and intensity, sometimes leading to disability or even death. Eosinophilic asthma accounts for 25% of cases of severe asthma. It is mediated by eosinophils regulated by interleukin...
作者:Kartikeya Tripathi MD, Joseph D Feuerstein MD
来源:[J].Drugs in Context, 2019BioExcel出版社
摘要:Ulcerative colitis (UC) is a chronic idiopathic inflammatory disorder that involves any part of the colon starting in the rectum in a continuous fashion presenting typically with symptoms such as bloody diarrhea, abdominal pain, and rectal urgency. UC is diagnosed based on clinic...
作者:Carlos Henrique Ferreira Camargo MD, MSc, PhD, Hélio Afonso Ghizoni Teive MD, MSc, PhD
来源:[J].Drugs in Context, 2019BioExcel出版社
摘要:The term movement disorders encompasses all disorders hypokinetic and hyperkinetic, which were previously known as extrapyramidal syndromes. With the definition of movement disorders and their diagnostic criteria and classifications, new studies for therapeutics could be performe...
作者:Natasha A Jain MD, Gregory A Otterson MD
来源:[J].Drugs in Context, 2019BioExcel出版社
摘要:The leading cause of cancer-related deaths in the United States continues to be lung cancer. Approximately 25–30% of patients are diagnosed with locally advanced nonsmall cell lung cancer (NSCLC). Concurrent chemoradiation with a platinum-based doublet is the current standar...
作者:Alexander KC Leung MBBS, FRCPC, FRCP (UK and Irel), FRCPCH, FAAP, Kam Lun Hon MD, FAAP, FCCM
来源:[J].Drugs in Context, 2019BioExcel出版社
摘要:Background: Gastroesophageal reflux is a common disorder in pediatrics. Clinicians should be familiar with the proper evaluation and management of this condition. Objective: To provide an update on the current understanding, evaluation, and management of gastroesophageal ref...
作者:Fernando Pérez-Ruiz MD, PhD, Tim Jansen MD, Anne-Katrin Tausche MD, Mónica Juárez-Campo BSc, Ravichandra Karra Gurunath MD, Pascal Richette MD, PhD
来源:[J].Drugs in Context, 2019BioExcel出版社
摘要:The aim of this review is to present current evidence about the efficacy and safety of lesinurad in combination with xanthine oxidase inhibitors (XOIs) in the treatment of hyperuricemia in patients with gout. Gout is the most common inflammatory form of arthritis. It is caused by...
作者:Alessandro Giallongo MD, Giuseppe Fabio Parisi MD, Amelia Licari MD, Giulio Pulvirenti MD, Caterina Cuppari MD, Carmelo Salpietro MD, Gian Luigi Marseglia MD, Salvatore Leonardi MD
来源:[J].Drugs in Context, 2019BioExcel出版社
摘要:The aim of precision medicine is setting up targeted therapies for selected patients that would ideally have high effectiveness and few side effects. This is made possible by targeted therapy drugs that selectively act on a specific pathway. Precision medicine is spreading to man...
作者:Miguel Nogueira MD, Tiago Torres MD, PhD
来源:[J].Drugs in Context, 2019BioExcel出版社
摘要:Psoriasis is a chronic, immune-mediated, inflammatory, and debilitating skin disease with significant impact on patients’ quality of life. Its pathogenesis is complex and not yet fully understood. However, the IL-23/IL-17 axis is currently considered the main pathogenic path...
作者:Federico Lavorini MD, PhD
来源:[J].Drugs in Context, 2019BioExcel出版社
摘要:Inhalation therapy is likely to continue to dominate asthma and chronic obstructive pulmonary disease (COPD) treatment. The pressurised metered-dose inhaler (pMDI) accounts for most of the global inhaler market, but this kind of device is difficult to use properly. Dry powde...
作者:Daniele Orsucci MD, Elena Caldarazzo Ienco MD, Gabriele Siciliano MD, PhD, Michelangelo Mancuso MD, PhD
来源:[J].Drugs in Context, 2019BioExcel出版社
摘要:Mitochondrial disorders are a group of metabolic conditions caused by impairment of the oxidative phosphorylation system. There is currently no clear evidence supporting any pharmacological interventions for most mitochondrial disorders, except for coenzyme Q10 deficiencies,...

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