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作者:Ignacio Marín-Jiménez MD, PhD, Cristina Saro MD, Verónica Díaz PhD, Manuel Barreiro-de Acosta MD, PhD, María Gómez-García MD, PhD, Ana Gutiérrez Casbas PhD, on behalf of the working group of EPICURE study
来源:[J].Drugs in Context, 2018BioExcel出版社
摘要:Background and aim: Nationwide epidemiological data on ulcerative colitis (UC) in Spain are lacking. The primary objective was to assess the epidemiology of UC at hospital gastroenterology units and the use of hospital resources (characteristics and facilities) for the manag...
作者:Hanh Thi Pham PhD, Thibault Mesplède PhD
来源:[J].Drugs in Context, 2018BioExcel出版社
摘要:Human immunodeficiency virus type 1 (HIV-1) infection remains a major health issue worldwide. In developed countries, antiretroviral therapy has extended its reach from treatment of people living with HIV-1 to post-exposure prophylaxis, treatment as prevention, and, more rec...
作者:Sonia Brugnara, Mariacristina Sicher, Elena Maria Bonandini, Davide Donner, Franca Chierichetti, Mattia Barbareschi, Carlo Renè Girardelli, Orazio Caffo
来源:[J].Drugs in Context, 2018BioExcel出版社
摘要:Here, we report the case of a patient, diagnosed with BRAF V600E-mutated metastatic malignant melanoma M1a, who achieved a complete metabolic response after 7 months of treatment with the combination of dabrafenib and trametinib. After 31 months, the treatment was...
作者:Elizabeth S Nakasone MD, PhD, Sara A Hurvitz MD, Kelly E McCann MD, PhD
来源:[J].Drugs in Context, 2018BioExcel出版社
摘要:Breast cancer is the most prevalent malignancy in women and the second most common cause of cancer-related death worldwide. Despite major innovations in early detection and advanced therapeutics, up to 30% of women with nodenegative breast cancer and 70% of women with node-positi...
作者:Tomas Fait, Dmitry Buryak, Monica-Mihaela Cirstoiu, Eva Luczai, Rafal Janczura
来源:[J].Drugs in Context, 2018BioExcel出版社
摘要:Background: The availability of various oral contraceptive (OC) pill formulations with different hormone compositions suggests that there is potential to align a particular product with an individual user’s needs and preferences. To explore this concept further, a survey was...
作者:Youngjung Kim, Laura Hack, Elizabeth S Ahn, Jungjin Kim
来源:[J].Drugs in Context, 2018BioExcel出版社
摘要:Alcohol use disorder (AUD) is commonly encountered in clinical practice. A combination of psychosocial intervention and pharmacotherapy is the cornerstone of AUD treatment. Despite their efficacy, safety and cost-effectiveness, clinicians are reluctant to prescribe medications to...
作者:Rajesh R Tampi, Geetha Manikkara, Silpa Balachandran, Piyush Taparia, Stephanie Hrisko, Shilpa Srinivasan, Deena J Tampi
来源:[J].Drugs in Context, 2018BioExcel出版社
摘要:The aim of this review was to identify published randomized control trials (RCTs) that evaluated the efficacy and tolerability of suvorexant for the treatment of insomnia among older adults (≥65 years). A literature search was conducted of PubMed, MEDLINE, EMBASE, PsycINFO a...
作者:Sanjay Kalra, Gagan Priya
来源:[J].Drugs in Context, 2018BioExcel出版社
摘要:While lipids are an integral part of the endocrine clinic, the opposite is not necessarily true. The lipocrinology framework addresses this lacuna, by highlighting the similarities and multiple relationships between lipid and endocrine function. It reinforces the need to screen (...
作者:Kam Lun Hon, Alexander KC Leung, Eddie Cheung, Bryan Lee, Michelle MC Tsang, Alcy R Torres
来源:[J].Drugs in Context, 2018BioExcel出版社
摘要:Alcohol addiction and intoxication are major health problems worldwide. Acute alcohol intoxication is well reported in adults and adolescents but less frequently reported in children of younger ages. We report three anonymized cases of pediatric ethanol exposure and illustrate th...
作者:Margarita SaizSatjes, Francisco Javier Martinez-Martin
来源:[J].Drugs in Context, 2018BioExcel出版社
摘要:Antihypertensive treatment of patients with diabetes should include those drugs with a positive effect on metabolic parameters. Most patients with diabetes require at least two antihypertensive agents. Combining a dihydropyridine calcium channel blocker with a renin-angiotensin-a...

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