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作者:Rui Chen , Qian Zhao , Ni Wu ...
来源:[J].Int. Journal of Clinical Pharmacology and Therapeutics(IF 1.2), 2019, Vol.57 (12), pp.596-602Dustri出版社
摘要:Objectives: To evaluate the pharmacokinetics of PC-SOD after single intravenous administration and its safety profile in healthy Chinese subjects. Materials and methods: This was a phase 1, randomized, double-blind, placebo-controlled, sequential, single-dose, and dose-escal...
作者:Anthony J. Bleyer , Kendrah Kidd , Emily Johnson ...
来源:[J].Clinical Nephrology(IF 1.288), 2019, Vol.92 (6), pp.302-311Dustri出版社
摘要:Aims: The reaction to diagnosis and quality of life (QOL) in autosomal dominant tubulointerstitial kidney disease (ADTKD) due to UMOD and MUC mutations from the time of diagnosis until treatment for end-stage kidney disease (ESKD) has not been characterized. It is unclear ho...
作者:Chao Lu , Yaru Yang , Qian Zhang ...
来源:[J].Int. Journal of Clinical Pharmacology and Therapeutics(IF 1.2), 2019, Vol.57 (12), pp.623-632Dustri出版社
摘要:Objective: This study was conducted to evaluate the pharmacokinetics and bioequivalence of two emtricitabine (FTC)/tenofovir disoproxil fumarate (TDF) tablets: a newly developed generic formulation (test) and a branded formulation (reference) in healthy Chinese subjects unde...
作者:Jeong-Soo Park , Ji-Young Jeon , Min-Gul Kim
来源:[J].Int. Journal of Clinical Pharmacology and Therapeutics(IF 1.2), 2019, Vol.57 (12), pp.612-622Dustri出版社
摘要:Context: A fixed-dose combination (FDC) tablet of amlodipine and rosuvastatin was recently developed for the treatment of concomitant hypertension and dyslipidemia and is anticipated to improve medication compliance. Objective: This study was performed to compare the single-...
作者:Koutaro Yokote , Akiyuki Suzuki , Yinhua Li ...
来源:[J].Int. Journal of Clinical Pharmacology and Therapeutics(IF 1.2), 2019, Vol.57 (12), pp.575-589Dustri出版社
摘要:Objective: Bococizumab, a monoclonal antibody targeting proprotein convertase subtilisin/kexin type 9, has been shown to reduce low-density lipoprotein cholesterol (LDL-C). Here, we describe the pharmacokinetics and pharmacodynamics of bococizumab and its effect on lipoprote...
作者:Sarah Di Bartolomeo , Stacey Rolak , Emily Joachim ...
来源:[J].Clinical Nephrology(IF 1.288), 2019, Vol.92 (6), pp.293-301Dustri出版社
摘要:Kidney transplant recipients (KTRs) have an increased risk of skin cancer. We analyzed the outcomes of KTRs transplanted at our center between January 1, 1994, and December 31, 2015, who reported pretransplant melanoma or had post-transplant de novo melanoma. Of 6,522 kidney...
作者:Catherine Joseph , Shweta Shah , Jessica Geer ...
来源:[J].Clinical Nephrology(IF 1.288), 2019, Vol.92 (6), pp.279-286Dustri出版社
摘要:Background: Management of chronic kidney disease mineral bone disorder (CKD-MBD) in pediatric patients with end-stage renal disease (ESRD) is challenging. While the use of calcimimetics is well-studied in adults on dialysis, few studies have been performed in pediatrics. Lit...
作者:Simon Leclerc , Louis-Philippe Laurin , Jean-Philippe Lafrance ...
来源:[J].Int. Journal of Clinical Pharmacology and Therapeutics(IF 1.2), 2019, Vol.57 (12), pp.603-606Dustri出版社
摘要:Residual renal function and diuresis preservation are associated with improved volume control and lower mortality in peritoneal dialysis (PD). Loop diuretics are used to maintain diuresis, although their optimal dosage remains unclear. This study aimed to compare the pharmacodyna...
作者:Grace Tamara Moscoso-Solorzano , Andrea Gabriela Farfan Jimenez
来源:[J].Clinical Nephrology(IF 1.288), 2019, Vol.92 (6), pp.319-324Dustri出版社
摘要:Background: Pregnancy is uncommon in women with chronic kidney disease (CKD), even more so in end-stage renal diseases (ESRD), and it is associated with high risks and complications that could lead to fetal and maternal morbidity or mortality and adverse outcomes. Material a...
作者:Špela Borštnar , Jelka Lindič , Luka Ležaič ...
来源:[J].Clinical Nephrology(IF 1.288), 2019, Vol.92 (6), pp.287-292Dustri出版社
摘要:Aim: The use of glomerular filtration rate (GFR) estimating equations is not always reliable, especially in specific populations, such as patients with transplanted kidney. The purpose of this study was to improve the performance of GFR equations by taking into account dry l...

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