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作者:Alfonso Iorio , Kathelijn Fischer , Victor Blanchette ...
来源:[J].Thromb Haemost(IF 6.094), 2017, Vol.117 (6), pp.1023-1030Schattauer 出版社
摘要:The prophylactic administration of factor IX (FIX) is considered the most effective treatment for haemophilia B. The inter-individual variability and complexity of the pharmacokinetics (PK) of FIX, and the rarity of the disease have hampered identification of an optimal treatment...
作者:Cristina Barale , Simona Buracco , Franco Cavalot ...
来源:[J].Thromb Haemost(IF 6.094), 2017, Vol.117 (6), pp.1115-1128Schattauer 出版社
摘要:Glucagon-like peptide 1 (GLP-1) is object of intensive investigation for not only its metabolic effects but also the protective vascular actions. Since platelets exert a primary role in the pathogenesis of atherosclerosis, inflammation and vascular complications, we investig...
作者:Dorian L. Culmer , Misha L. Dunbar , Angela E. Hawley ...
来源:[J].Thromb Haemost(IF 6.094), 2017, Vol.117 (6), pp.1171-1181Schattauer 出版社
摘要:Selectins, such as E-selectin (CD62E), function in venous thrombosis by binding and activating immune cells to initiate the coagulation cascade. GMI-1271 is a small molecule antagonist that inhibits E-selectin activity. Here we determine whether inhibition of E-selectin is suffic...
作者:Frederikus A. Klok , Stefano Barco , Stavros V. Konstantinides
来源:[J].Thromb Haemost(IF 6.094), 2017, Vol.117 (6), pp.1164-1170Schattauer 出版社
摘要:One of the main determinants of establishing the optimal treatment duration of patients with venous thromboembolism (VTE) is the risk of major bleeding during long-term anticoagulant therapy. The 6-variable VTE-BLEED score was recently developed to enable estimation of this ...
作者:Xiaoyan (Shawn) Li , Steve Deitelzweig , Allison Keshishian ...
来源:[J].Thromb Haemost(IF 6.094), 2017, Vol.117 (6), pp.1072-1082Schattauer 出版社
摘要:The ARISTOTLE trial showed a risk reduction of stroke/systemic embolism (SE) and major bleeding in non-valvular atrial fibrillation (NVAF) patients treated with apixaban compared to warfarin. This retrospective study used four large US claims databases (MarketScan, PharMetri...
作者:Madhvi Rajpurkar , Tina Biss , Ernest K. Amankwah ...
来源:[J].Thromb Haemost(IF 6.094), 2017, Vol.117 (6), pp.1199-1207Schattauer 出版社
摘要:Data on paediatric pulmonary embolism (PE) are scarce. We sought to systematically review the current literature on childhood PE and conducted a search on paediatric PE via PubMed (1946–2013) and Embase (1980–2013). There was significant heterogeneity in reported data. Two p...
作者:Lorenzo Alberio , Catherine Ravanat ,  ...
来源:[J].Thromb Haemost(IF 6.094), 2017, Vol.117 (6), pp.1101-1114Schattauer 出版社
摘要:The combined action of collagen and thrombin induces the formation of COAT platelets, which are characterised by a coat of procoagulant and adhesive molecules on their surface. Although recent work has started to highlight their clinical relevance, the exact mechanisms regulating...

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