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作者:Ivana Strazic Geljic , Paola Kucan Brlic , Guillem Angulo ...
来源:[J].eLife, 2020, Vol.9eLife科学出版社
摘要:Cytomegaloviruses (CMVs) are ubiquitous pathogens known to employ numerous immunoevasive strategies that significantly impair the ability of the immune system to eliminate the infected cells. Here, we report that the single mouse CMV (MCMV) protein, m154, downregulates multiple s...
作者:Sandra Winters , William L Allen , James P Higham
来源:[J].eLife, 2020, Vol.9eLife科学出版社
摘要:Discriminating conspecifics from heterospecifics can help avoid costly interactions between closely related sympatric species. The guenons, a recent primate radiation, exhibit high degrees of sympatry and form multi-species groups. Guenons have species-specific colorful face patt...
作者:Mor Gross-Vered , Sébastien Trzebanski , Anat Shemer ...
来源:[J].eLife, 2020, Vol.9eLife科学出版社
摘要:Monocytes are circulating short-lived macrophage precursors that are recruited on demand from the blood to sites of inflammation and challenge. In steady state, classical monocytes give rise to vasculature-resident cells that patrol the luminal side of the endothelium. In ad...
作者:Harrison Tudor Evans , Liviu-Gabriel Bodea , Jürgen Götz
来源:[J].eLife, 2020, Vol.9eLife科学出版社
摘要:The formation of spatial long-term memory (LTM) requires the de novo synthesis of distinct sets of proteins; however, a non-biased examination of the de novo proteome in this process is lacking. Here, we generated a novel mouse strain, which enables cell-type-specific labelling o...
作者:Weidong Feng , Yinan Li , Pauline Dao ...
来源:[J].eLife, 2020, Vol.9eLife科学出版社
摘要:To become and remain functional, individual neuron types must select during development and maintain throughout life their distinct terminal identity features, such as expression of specific neurotransmitter receptors, ion channels and neuropeptides. Here, we report a molecu...
作者:Adrien Birot , Marta Tormos-Pérez , Sabine Vaur ...
来源:[J].eLife, 2020, Vol.9eLife科学出版社
摘要:Cohesin has essential roles in chromosome structure, segregation and repair. Cohesin binding to chromosomes is catalyzed by the cohesin loader, Mis4 in fission yeast. How cells fine tune cohesin deposition is largely unknown. Here, we provide evidence that Mis4 activity is regula...
作者:Martina Riva , Ioana Genescu , Chloé Habermacher ...
来源:[J].eLife, 2019, Vol.8eLife科学出版社
摘要:Programmed cell death and early activity contribute to the emergence of functional cortical circuits. While most neuronal populations are scaled-down by death, some subpopulations are entirely eliminated, raising the question of the importance of such demise for cortical wiring. ...
作者:Benjamin A Clarke , Saurav Majumder , Hongling Zhu ...
来源:[J].eLife, 2019, Vol.8eLife科学出版社
摘要:Sphingolipids are membrane and bioactive lipids that are required for many aspects of normal mammalian development and physiology. However, the importance of the regulatory mechanisms that control sphingolipid levels in these processes is not well understood. The mammalian ORMDL ...
作者:Rohit Singh , Beom K Choi
来源:[J].eLife, 2019, Vol.8eLife科学出版社
摘要:Lymph nodes (LNs) are a common site of metastasis in solid cancers, and cutaneous melanomas show inherent properties of LN colonization. However, interactions between LN stroma and pioneer metastatic cells during metastatic colonization remain largely uncharacterized. Here w...
作者:Paula J Bucko , Chloe K Lombard , Lindsay Rathbun ...
来源:[J].eLife, 2019, Vol.8eLife科学出版社
摘要:Deciphering how signaling enzymes operate within discrete microenvironments is fundamental to understanding biological processes. A-kinase anchoring proteins (AKAPs) restrict the range of action of protein kinases within intracellular compartments. We exploited the AKAP targ...

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