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作者:Shun Tu , Shu-Juan Guo , Chien-Sheng Chen ...
来源:[J].eLife, 2015, Vol.4eLife科学出版社
摘要:Reversible lysine acetylation is one of the most important protein posttranslational modifications that plays essential roles in both prokaryotes and eukaryotes. However, only a few lysine deacetylases (KDACs) have been identified in prokaryotes, perhaps in part due to their...
作者:Sari Tojkander , Gergana Gateva , Amjad Husain ...
来源:[J].eLife, 2015, Vol.4eLife科学出版社
摘要:Adhesion and morphogenesis of many non-muscle cells are guided by contractile actomyosin bundles called ventral stress fibers. While it is well established that stress fibers are mechanosensitive structures, physical mechanisms by which they assemble, align, and mature have ...
作者:Juha Saarikangas , Yves Barral
来源:[J].eLife, 2015, Vol.4eLife科学出版社
摘要:Differentiation of cellular lineages is facilitated by asymmetric segregation of fate determinants between dividing cells. In budding yeast, various aging factors segregate to the aging (mother)-lineage, with poorly understood consequences. In this study, we show that yeast ...
作者:Yi-Zhi Wang , Jing-Jing Wang , Yu Huang ...
来源:[J].eLife, 2015, Vol.4eLife科学出版社
摘要:Acidotoxicity is common among neurological disorders, such as ischemic stroke. Traditionally, Ca2+ influx via homomeric acid-sensing ion channel 1a (ASIC1a) was considered to be the leading cause of ischemic acidotoxicity. Here we show that extracellular protons trigge...
作者:Jeremy Freeman , Greg D Field , Peter H Li ...
来源:[J].eLife, 2015, Vol.4eLife科学出版社
摘要:The function of a neural circuit is shaped by the computations performed by its interneurons, which in many cases are not easily accessible to experimental investigation. Here, we elucidate the transformation of visual signals flowing from the input to the output of the primate r...
作者:Ying-Ju Chang , Scott Pownall , Thomas E Jensen ...
来源:[J].eLife, 2015, Vol.4eLife科学出版社
摘要:Adipose tissue is crucial for the maintenance of energy and metabolic homeostasis and its deregulation can lead to obesity and type II diabetes (T2D). Using gene disruption in the mouse, we discovered a function for a RhoA-specific guanine nucleotide exchange factor PDZ-RhoG...
作者:Olivier Britz , Jingming Zhang , Katja S Grossmann ...
来源:[J].eLife, 2015, Vol.4eLife科学出版社
摘要:V1 and V2b interneurons (INs) are essential for the production of an alternating flexor–extensor motor output. Using a tripartite genetic system to selectively ablate either V1 or V2b INs in the caudal spinal cord and assess their specific functions in awake behaving animals...
作者:Stephen N Gomperts , Fabian Kloosterman , Matthew A Wilson
来源:[J].eLife, 2015, Vol.4eLife科学出版社
摘要:Spatial learning requires the hippocampus, and the replay of spatial sequences during hippocampal sharp wave-ripple (SPW-R) events of quiet wakefulness and sleep is believed to play a crucial role. To test whether the coordination of VTA reward prediction error signals with ...
作者:Zenas C Chao , Yasuo Nagasaka , Naotaka Fujii
来源:[J].eLife, 2015, Vol.4eLife科学出版社
摘要:Context is information linked to a situation that can guide behavior. In the brain, context is encoded by sensory processing and can later be retrieved from memory. How context is communicated within the cortical network in sensory and mnemonic forms is unknown due to the la...
作者:Philipp Khuc Trong , Hélène Doerflinger , Jörn Dunkel ...
来源:[J].eLife, 2015, Vol.4eLife科学出版社
摘要:Many cells contain non-centrosomal arrays of microtubules (MTs), but the assembly, organisation and function of these arrays are poorly understood. We present the first theoretical model for the non-centrosomal MT cytoskeleton in Drosophila oocytes, in which bicoid and oskar mRNA...

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