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作者:Elisabeth A Geyer , Matthew P Miller , Chad A Brautigam ...
来源:[J].eLife, 2018, Vol.7eLife科学出版社
摘要:Stu2/XMAP215 microtubule polymerases use multiple tubulin-binding TOG domains and a lattice-binding basic region to processively promote faster elongation. How the domain composition and organization of these proteins dictate polymerase activity, end localization, and proces...
作者:Mikiko Inaki , Ryo Hatori , Naotaka Nakazawa ...
来源:[J].eLife, 2018, Vol.7eLife科学出版社
摘要:Polarized epithelial morphogenesis is an essential process in animal development. While this process is mostly attributed to directional cell intercalation, it can also be induced by other mechanisms. Using live-imaging analysis and a three-dimensional vertex model, we ident...
作者:Eliot Dow , Adrian Jacobo , Sajjad Hossain ...
来源:[J].eLife, 2018, Vol.7eLife科学出版社
摘要:The lateral-line neuromast of the zebrafish displays a restricted, consistent pattern of innervation that facilitates the comparison of microcircuits across individuals, developmental stages, and genotypes. We used serial blockface scanning electron microscopy to determine from m...
作者:Sarah Adio , Heena Sharma , Tamara Senyushkina ...
来源:[J].eLife, 2018, Vol.7eLife科学出版社
摘要:Release factors RF1 and RF2 promote hydrolysis of peptidyl-tRNA during translation termination. The GTPase RF3 promotes recycling of RF1 and RF2. Using single molecule FRET and biochemical assays, we show that ribosome termination complexes that carry two factors, RF1–RF3 or...
作者:Prachee Avasthi , Alice Soragni , Joshua N Bembenek
来源:[J].eLife, 2018, Vol.7eLife科学出版社
摘要:Early-career researchers can learn about peer review by discussing preprints at journal clubs and sending feedback to the authors.
作者:Timothy F Miles , Katja Spiess , Kevin M Jude ...
来源:[J].eLife, 2018, Vol.7eLife科学出版社
摘要:Human cytomegalovirus has hijacked and evolved a human G-protein-coupled receptor into US28, which functions as a promiscuous chemokine 'sink’ to facilitate evasion of host immune responses. To probe the molecular basis of US28’s unique ligand cross-reactivity, we deep-seque...
作者:Andrew JR Plested
来源:[J].eLife, 2018, Vol.7eLife科学出版社
摘要:A simple label-free method uses the electrical properties of cells to detect how ligands bind to membrane proteins.
作者:Divyanshu Malhotra , Jimann Shin , Lilianna Solnica-Krezel ...
来源:[J].eLife, 2018, Vol.7eLife科学出版社
摘要:Chemokines are secreted proteins that regulate a range of processes in eukaryotic organisms. Interestingly, different chemokine receptors control distinct biological processes, and the same receptor can direct different cellular responses, but the basis for this phenomenon i...
作者:Jonna Alanko , Michael Sixt
来源:[J].eLife, 2018, Vol.7eLife科学出版社
摘要:In zebrafish larvae, it is the cell type that determines how the cell responds to a chemokine signal.
作者:Genevieve C Kendall , Sarah Watson , Lin Xu ...
来源:[J].eLife, 2018, Vol.7eLife科学出版社
摘要:Alveolar rhabdomyosarcoma is a pediatric soft-tissue sarcoma caused by PAX3/7-FOXO1 fusion oncogenes and is characterized by impaired skeletal muscle development. We developed human PAX3-FOXO1 -driven zebrafish models of tumorigenesis and found that PAX3-FOXO1 exhibits discr...

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