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作者:Amy M LeMessurier , Keven J Laboy-Juárez , Kathryn McClain ...
来源:[J].eLife, 2019, Vol.8eLife科学出版社
摘要:Sensory maps in layer (L) 2/3 of rodent cortex lack precise functional column boundaries, and instead exhibit locally heterogeneous (salt-and-pepper) tuning superimposed on smooth global topography. Could this organization be a byproduct of impoverished experience in laboratory h...
作者:Evan Witt , Sigi Benjamin , Nicolas Svetec ...
来源:[J].eLife, 2019, Vol.8eLife科学出版社
摘要:The testis is a peculiar tissue in many respects. It shows patterns of rapid gene evolution and provides a hotspot for the origination of genetic novelties such as de novo genes, duplications and mutations. To investigate the expression patterns of genetic novelties across cell t...
作者:George L Sutphin
来源:[J].eLife, 2019, Vol.8eLife科学出版社
摘要:Young Caenorhabditis elegans hermaphrodites use their own sperm to protect against the negative consequences of mating.
作者:Lesley K Fellows
来源:[J].eLife, 2019, Vol.8eLife科学出版社
摘要:A brain region known as the hippocampus is required when people assess different options before making a value-based choice.
作者:Maximilian AH Jakobs , Andrea Dimitracopoulos , Kristian Franze
来源:[J].eLife, 2019, Vol.8eLife科学出版社
摘要:Kymographs are graphical representations of spatial position over time, which are often used in biology to visualise the motion of fluorescent particles, molecules, vesicles, or organelles moving along a predictable path. Although in kymographs tracks of individual particles...
作者:Alessandro Sanzeni , Samata Katta , Bryan Petzold ...
来源:[J].eLife, 2019, Vol.8eLife科学出版社
摘要:Touch sensation hinges on force transfer across the skin and activation of mechanosensitive ion channels along the somatosensory neurons that invade the skin. This skin-nerve sensory system demands a quantitative model that spans the application of mechanical loads to channe...
作者:Valentina Bonnefil , Karen Dietz , Mario Amatruda ...
来源:[J].eLife, 2019, Vol.8eLife科学出版社
摘要:Exposure to stress increases the risk of developing mood disorders. While a subset of individuals displays vulnerability to stress, others remain resilient, but the molecular basis for these behavioral differences is not well understood. Using a model of chronic social defea...
作者:Ksenya Cohen Katsenelson , Joshua D Stender , Agnieszka T Kawashima ...
来源:[J].eLife, 2019, Vol.8eLife科学出版社
摘要:Inflammation is an essential aspect of innate immunity but also contributes to diverse human diseases. Although much is known about the kinases that control inflammatory signaling, less is known about the opposing phosphatases. Here we report that deletion of the gene encoding PH...
作者:Suk ho Hong , Neel H Shah
来源:[J].eLife, 2019, Vol.8eLife科学出版社
摘要:Predicting ancestral sequences of protein kinases reveals the molecular details that underlie different modes of activation.

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