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作者:Andrew R McKinstry-Wu , Andrzej Z Wasilczuk , Benjamin A Harrison ...
来源:[J].eLife, 2019, Vol.8eLife科学出版社
摘要:Traditionally, drug dosing is based on a concentration-response relationship estimated in a population. Yet, in specific individuals, decisions based on the population-level effects frequently result in over or under-dosing. Here, we interrogate the relationship between populatio...
作者:Elias T Friman , Cédric Deluz , Antonio CA Meireles-Filho ...
来源:[J].eLife, 2019, Vol.8eLife科学出版社
摘要:The pioneer activity of transcription factors allows for opening of inaccessible regulatory elements and has been extensively studied in the context of cellular differentiation and reprogramming. In contrast, the function of pioneer activity in self-renewing cell divisions and ac...
作者:Allison M Owen , Samir P Patel , Jeffrey D Smith ...
来源:[J].eLife, 2019, Vol.8eLife科学出版社
摘要:Chronic critical illness is a global clinical issue affecting millions of sepsis survivors annually. Survivors report chronic skeletal muscle weakness and development of new functional limitations that persist for years. To delineate mechanisms of sepsis-induced chronic weakness,...
作者:Raphael M Bendriem , Shawn Singh , Alice Abdel Aleem ...
来源:[J].eLife, 2019, Vol.8eLife科学出版社
摘要:Occludin ( OCLN ) mutations cause human microcephaly and cortical malformation. A tight junction component thought absent in neuroepithelium after neural tube closure, OCLN isoform-specific expression extends into corticogenesis. Full-length and truncated isoforms localize to neu...
作者:Carla Verna , Sree Janani Ravichandran , Megan G Sawchuk ...
来源:[J].eLife, 2019, Vol.8eLife科学出版社
摘要:Plants coordinate the polarity of hundreds of cells during vein formation, but how they do so is unclear. The prevailing hypothesis proposes that GNOM, a regulator of membrane trafficking, positions PIN-FORMED auxin transporters to the correct side of the plasma membrane; th...
作者:Cynthia B Silveira , Antoni Luque , Ty NF Roach ...
来源:[J].eLife, 2019, Vol.8eLife科学出版社
摘要:The microbialization of coral reefs predicts that microbial oxygen consumption will cause reef deoxygenation. Here we tested this hypothesis by analyzing reef microbial and primary producer oxygen metabolisms. Metagenomic data and in vitro incubations of bacteria with primary pro...
作者:Míriam Osés-Ruiz , Nicholas J Talbot
来源:[J].eLife, 2019, Vol.8eLife科学出版社
摘要:The corn smut fungus uses two different mechanisms to control its cell cycle when it is infecting plants.
作者:Lorena Armijo-Weingart , Andrea Ketschek , Rajiv Sainath ...
来源:[J].eLife, 2019, Vol.8eLife科学出版社
摘要:Neurotrophins are growth factors that have a multitude of roles in the nervous system. We report that neurotrophins induce the fission of mitochondria along embryonic chick sensory axons driven by combined PI3K and Mek-Erk signaling. Following an initial burst of fission, a new s...
作者:Irene Díaz-López , René Toribio , Juan José Berlanga ...
来源:[J].eLife, 2019, Vol.8eLife科学出版社
摘要:Loading of mRNA onto the ribosomal 43S pre-initiation complex (PIC) and its subsequent scanning require the removal of the secondary structure of the by RNA helicases such as eIF4A. However, the topology and mechanics of the scanning complex bound to mRNA (48S-PIC) and the i...
作者:Elena Rondeau , Nicolas Larmonier , Thomas Pradeu ...
来源:[J].eLife, 2019, Vol.8eLife科学出版社
摘要:Philosophers have explored the concept of causality for centuries. Here we argue that ideas about causality from philosophy can help scientists to better understand how cancerous tumors grow and spread in the body. After outlining six characteristics of causality that are relevan...

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