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作者:Alexandria H Jaeger , Molly Stanley , Zachary F Weiss ...
来源:[J].eLife, 2018, Vol.7eLife科学出版社
摘要:Each taste modality is generally encoded by a single, molecularly defined, population of sensory cells. However, salt stimulates multiple taste pathways in mammals and insects, suggesting a more complex code for salt taste. Here, we examine salt coding in Drosophila . After ...
作者:Arda Halu , Jian-Guo Wang , Hiroshi Iwata ...
来源:[J].eLife, 2018, Vol.7eLife科学出版社
摘要:The role of pro-inflammatory macrophage activation in cardiovascular disease (CVD) is a complex one amenable to network approaches. While an indispensible tool for elucidating the molecular underpinnings of complex diseases including CVD, the interactome is limited in its ut...
作者:Qinwen Liu , Pinar Onal , Rhea R Datta ...
来源:[J].eLife, 2018, Vol.7eLife科学出版社
摘要:The ancient mechanisms that caused developmental gene regulatory networks to diversify among distantly related taxa are not well understood. Here we use ancestral protein reconstruction, biochemical experiments, and developmental assays of transgenic animals carrying reconst...
作者:Damien Laporte , Laëtitia Gouleme , Laure Jimenez ...
来源:[J].eLife, 2018, Vol.7eLife科学出版社
摘要:Most cells spend the majority of their life in a non-proliferating state. When proliferation cessation is irreversible, cells are senescent. By contrast, if the arrest is only temporary, cells are defined as quiescent. These cellular states are hardly distinguishable without...
作者:Ashley RG Libby , David A Joy , Po-Lin So ...
来源:[J].eLife, 2018, Vol.7eLife科学出版社
摘要:Morphogenesis involves interactions of asymmetric cell populations to form complex multicellular patterns and structures comprised of distinct cell types. However, current methods to model morphogenic events lack control over cell-type co-emergence and offer little capabilit...
作者:Kelley Harris
来源:[J].eLife, 2018, Vol.7eLife科学出版社
摘要:Just 5% of the human genome is subject to neutral evolution, but this process remains central to understanding the history of human migration across the Earth.
作者:Isaac Casanovas-Vilar , Joan Garcia-Porta , Josep Fortuny ...
来源:[J].eLife, 2018, Vol.7eLife科学出版社
摘要:Flying squirrels are the only group of gliding mammals with a remarkable diversity and wide geographical range. However, their evolutionary story is not well known. Thus far, identification of extinct flying squirrels has been exclusively based on dental features, which, con...
作者:Drew M Altschul , William D Hopkins , Elizabeth S Herrelko ...
来源:[J].eLife, 2018, Vol.7eLife科学出版社
摘要:Life history strategies for optimizing individual fitness fall on a spectrum between maximizing reproductive efforts and maintaining physical health over time. Strategies across this spectrum are viable and different suites of personality traits evolved to support these stra...

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