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作者:Daniel Marten van Es , Jan Theeuwes , Tomas Knapen
来源:[J].eLife, 2018, Vol.7eLife科学出版社
摘要:Spatial attention changes the sampling of visual space. Behavioral studies suggest that feature-based attention modulates this resampling to optimize the attended feature's sampling. We investigate this hypothesis by estimating spatial sampling in visual cortex while indepen...
作者:Jian Guan , Nilabh Shastri
来源:[J].eLife, 2018, Vol.7eLife科学出版社
摘要:Why does cancer develop in situations where the immune system is perfectly capable of eliminating it?
作者:Shigetoshi Yokoyama , Yan Cai , Miyuki Murata ...
来源:[J].eLife, 2018, Vol.7eLife科学出版社
摘要:Intracellular lipopolysaccharide (LPS) triggers the non-canonical inflammasome pathway, resulting in pyroptosis of innate immune cells. In addition to its well-known proinflammatory role, LPS can directly cause regression of some tumors, although the underlying mechanism has rema...
作者:Molly OhAinle , Louisa Helms , Jolien Vermeire ...
来源:[J].eLife, 2018, Vol.7eLife科学出版社
摘要:Interferon (IFN) inhibits HIV replication by inducing antiviral effectors. To comprehensively identify IFN-induced HIV restriction factors, we assembled a CRISPR sgRNA library of Interferon Stimulated Genes (ISGs) into a modified lentiviral vector that allows for packaging of sgR...
作者:Iryna Shakhmantsir , Soumyashant Nayak , Gregory R Grant ...
来源:[J].eLife, 2018, Vol.7eLife科学出版社
摘要:Transcription-translation feedback loops that comprise eukaryotic circadian clocks rely upon temporal delays that separate the phase of active transcription of clock genes, such as Drosophila period (per) and timeless (tim), from negative feedback by the two proteins. However, ou...
作者:Eric CH Chen , Stephanie Mathieu , Anne Hoffrichter ...
来源:[J].eLife, 2018, Vol.7eLife科学出版社
摘要:Eukaryotes thought to have evolved clonally for millions of years are referred to as ancient asexuals. The oldest group among these are the arbuscular mycorrhizal fungi (AMF), which are plant symbionts harboring hundreds of nuclei within one continuous cytoplasm. Some AMF strains...
作者:Lori L O'Brien , Alexander N Combes , Kieran M Short ...
来源:[J].eLife, 2018, Vol.7eLife科学出版社
摘要:A normal endowment of nephrons in the mammalian kidney requires a balance of nephron progenitor self-renewal and differentiation throughout development. Here, we provide evidence for a novel action of ureteric branch tip-derived Wnt11 in progenitor cell organization and interacti...
作者:Didhiti Mukherjee , Greta Sokoloff , Mark S Blumberg
来源:[J].eLife, 2018, Vol.7eLife科学出版社
摘要:In week-old rats, somatosensory input arises predominantly from external stimuli or from sensory feedback (reafference) associated with myoclonic twitches during active sleep. A previous study suggested that the brainstem motor structures that produce twitches also send moto...
作者:Yu-Chen Chen , Pei-Heng Jiang , Hsuan-Ming Chen ...
来源:[J].eLife, 2018, Vol.7eLife科学出版社
摘要:Aging is an intricate phenomenon associated with the gradual loss of physiological functions, and both nutrient sensing and proteostasis control lifespan. Although multiple approaches have facilitated the identification of candidate genes that govern longevity, the molecular...
作者:Ruben Soto-Acosta , Xuping Xie , Chao Shan ...
来源:[J].eLife, 2018, Vol.7eLife科学出版社
摘要:Subgenomic flaviviral RNA (sfRNA) accumulates during infection due to incomplete degradation of viral genomes and interacts with cellular proteins to promote infection. Here we identify host proteins that bind the Zika virus (ZIKV) sfRNA. We identified fragile X mental retardatio...

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