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作者:Rafael Linden , Marina Venzon Antunes , Jose Luiz Costa
来源:[B].Elsevier Inc.2020Elsevier
摘要:This chapter presents an overview on the use of mass spectrometry assays for drug measurement in biosamples. Drug measurement in biological specimens, particularly in the context of therapeutic drug monitoring (TDM), requires the availability of robust and well-validated laborato...
作者:Andreas H. Groll , Silke Gastine
来源:[B].Elsevier Inc.2020Elsevier
摘要:Invasive fungal infections are important causes of morbidity and mortality in critically ill and immunocompromised patients. Since these infections remain difficult to diagnose and can be rapidly fatal, appropriate antifungal therapy is key to successful prevention, management, a...
作者:Georg Hempel
来源:[B].Elsevier Inc.2020Elsevier
摘要:Anticancer drugs are good candidates for therapeutic drug monitoring (TDM) because of their high toxicity and documented exposure–response relationship for many anticancer drugs. In contrast to this, a few years ago Peterson concluded that in oncology “…plasma concentra...
作者:Wolfgang Thormann
来源:[B].Elsevier Inc.2020Elsevier
摘要:Capillary electrophoresis (CE) is an effective and economic tool for analysis of licit and illicit drugs and their metabolites in biological samples. This chapter provides a brief overview of the principles of CE, the features of CE instrumentation and the key aspects of CE-based...
作者:Cecilie Johannessen Landmark , Svein I. Johannessen
来源:[B].Elsevier Inc.2020Elsevier
摘要:The aim of the present chapter is to discuss therapeutic drug monitoring (TDM) of antiepileptic drugs (AEDs), based on their pharmacokinetic properties in order to optimize the therapy to the individual patient. Due to the nature of epilepsy, it remains problematic to monito...
作者:Philip B. Mitchell
来源:[B].Elsevier Inc.2020Elsevier
摘要:Over recent decades major advances have occurred in the pharmacological management of depression and schizophrenia. Despite this, high rates of poor compliance and considerable genetic variability in metabolism have meant that the practical application of such treatments has ofte...
作者:Christoph Seger
来源:[B].Elsevier Inc.2020Elsevier
摘要:Therapeutic drug monitoring of immunosuppressive drugs, namely, cyclosporine A, tacrolimus, sirolimus, everolimus, and mycophenolic acid, is an accepted measurement service that strongly supports transplantation medicine worldwide. During the past twenty years, ligand-bindin...
作者:Zhuo Shao , Lianna G. Kyriakopoulou , Shinya Ito
来源:[B].Elsevier Inc.2020Elsevier
摘要:Pharmacogenomics (PGx) (used interchangeably with pharmacogenetics) evaluates a person's response to medications based on his or her genetic makeup. The field was established since 1950s and grew exponentially since the completion of Human Genome Project. Recently establishe...

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