Bentham期刊
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作者:Robert Musiol
来源:[J].Medicinal Chemistry(IF 1.373), 2020, Vol.16 (2), pp.141-154Bentham
摘要:Background: Styrylquinolines are characteristic fully aromatic compounds with flat, rather lipophilic structures. The first reports on their synthesis and biological activity were published roughly a century ago. However, their low selectivity, unfavorable toxicity and problems w...
作者:F. Ansari , J B. Ghasemi , A. Niazi
来源:[J].Medicinal Chemistry(IF 1.373), 2020, Vol.16 (2), pp.155-168Bentham
摘要:Background: Three dimensional quantitative structure activity relationship and pharmacophore modeling are studied for tacrine derivatives as acetylcholinesterase inhibitors. Methods: The three dimensional quantitative structure–activity relationship and pharmacophore methods...
作者:Nehaben A. Gujarati , Bradley J. Undem , Vijaya L. Korlipara
来源:[J].Medicinal Chemistry(IF 1.373), 2020, Vol.16 (2), pp.202-211Bentham
摘要:Background: The inhibition of transient receptor potential vanilloid receptor 1 (TRPV1 has emerged as a novel approach for the treatment of various pain states. Pyrrolidinyl urea, SB 705498 with pKb = 7.3 in guinea pig TRPV1 receptor has been investigated in Phase II clinical tri...
作者:Nikolaos E. Labrou
来源:[J].Recent Patents on Biotechnology, 2020, Vol.14 (1), pp.4-4Bentham
作者:Sarosh Iqbal , Ajmal Khan , Rashid Nazir ...
来源:[J].Medicinal Chemistry(IF 1.373), 2020, Vol.16 (2), pp.244-255Bentham
摘要:Background: Peptic ulcer and urolithiasis are largely due to infection caused by ureaseproducing bacteria. Therefore, the discovery of urease inhibitors is an important area of medicinal chemistry research. Objective: The main aim of the work was to identify novel urease inh...
作者:Shweta Chauhan , Varun Jaiswal , Chandrika Attri ...
来源:[J].Recent Patents on Biotechnology, 2020, Vol.14 (1), pp.5-15Bentham
摘要:Background: Xylanases of thermophilic origin are more robust and stable and hence more suitable for industrial applications. The aim of the research was to develop a patent using a robust mutant exhibiting enhanced xylanase activity. The strain (Bacillus aestuarii SC-2014 subject...
作者:Tanzeela A. Fattah , Aamer Saeed , Zaman Ashraf ...
来源:[J].Medicinal Chemistry(IF 1.373), 2020, Vol.16 (2), pp.229-243Bentham
摘要:Background: Urease enzyme catalyzes the hydrolysis of urea into ammonia and CO2, excess ammonia causes global warming and crop reduction. Ureases are also responsible for certain human diseases such as stomach cancer, peptic ulceration, pyelonephritis, and kidney stones. New...
作者:Richa Kaur Bhatia , Lakhwinder Singh , Ruchika Garg ...
来源:[J].Medicinal Chemistry(IF 1.373), 2020, Vol.16 (2), pp.212-228Bentham
摘要:Background: Novel 4-[3-(6/7/8-Substituted 4-Oxo-4H-chromen-3-ylacryloyl]phenylboronic acid derivatives (5a-h as well as other 6/7/8-substituted-3-(3-oxo-3-(4-substitutedphenylprop-1-enyl-4H-chromen-4-one derivatives (3a-u have been designed as p53 -MDM2 pathway inhibitors an...
作者:Mohammed A. Alamri , Zeynep Ates Alagoz , Adeboye Adejare
来源:[J].Medicinal Chemistry(IF 1.373), 2020, Vol.16 (2), pp.192-201Bentham
摘要:Background: Novel bicycloheptylamines were designed and synthesized. These compounds were found to be selective for sigma-2 receptors. These receptors have been found to be up to 10 fold over-expressed in certain cancer cell lines, leading to investigation of possible uses a...

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