Annual Reviews期刊
期刊
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作者:Hans-Wilhelm Nützmann , Claudio Scazzocchio , Anne Osbourn
来源:[J].Annual Review of Genetics(IF 17.436), 2018, Vol.52, pp.159-183Annual Reviews
摘要:In bacteria, more than half of the genes in the genome are organized in operons. In contrast, in eukaryotes, functionally related genes are usually dispersed across the genome. There are, however, numerous examples of functional clusters of nonhomologous genes for metabolic pathw...
作者:Sigrid Nachtergaele , Chuan He
来源:[J].Annual Review of Genetics(IF 17.436), 2018, Vol.52, pp.349-372Annual Reviews
摘要:Investigations over the past eight years of chemical modifications on messenger RNA (mRNA) have revealed a new level of posttranscriptional gene regulation in eukaryotes. Rapid progress in our understanding of these modifications, particularly, N6-methyladenosine (m...
作者:Sabrina Y. Stanley , Karen L. Maxwell
来源:[J].Annual Review of Genetics(IF 17.436), 2018, Vol.52, pp.445-464Annual Reviews
摘要:The battle for survival between bacteria and bacteriophages (phages) is an arms race where bacteria develop defenses to protect themselves from phages and phages evolve counterstrategies to bypass these defenses. CRISPR-Cas adaptive immune systems represent a widespread mechanism...
作者:Jason G. Wallace , Eli Rodgers-Melnick , Edward S. Buckler
来源:[J].Annual Review of Genetics(IF 17.436), 2018, Vol.52, pp.421-444Annual Reviews
摘要:Understanding the quantitative genetics of crops has been and will continue to be central to maintaining and improving global food security. We outline four stages that plant breeding either has already achieved or will probably soon achieve. Top-of-the-line breeding programs are...
作者:Andrew Seeber , Michael H. Hauer , Susan M. Gasser
来源:[J].Annual Review of Genetics(IF 17.436), 2018, Vol.52, pp.295-319Annual Reviews
摘要:Recent advances in both the technologies used to measure chromatin movement and the biophysical analysis used to model them have yielded a fuller understanding of chromatin dynamics and the polymer structure that underlies it. Changes in nucleosome packing, checkpoint kinase...
作者:Benjamin Czech , Marzia Munafò , Filippo Ciabrelli ...
来源:[J].Annual Review of Genetics(IF 17.436), 2018, Vol.52, pp.131-157Annual Reviews
摘要:PIWI-interacting RNAs (piRNAs) and their associated PIWI clade Argonaute proteins constitute the core of the piRNA pathway. In gonadal cells, this conserved pathway is crucial for genome defense, and its main function is to silence transposable elements. This is achieved through ...
作者:Jerome Mertens , Dylan Reid , Shong Lau ...
来源:[J].Annual Review of Genetics(IF 17.436), 2018, Vol.52, pp.271-293Annual Reviews
摘要:Age-associated neurological diseases represent a profound challenge in biomedical research as we are still struggling to understand the interface between the aging process and the manifestation of disease. Various pathologies in the elderly do not directly result from genetic mut...
作者:Lei Zhang , Jan Vijg
来源:[J].Annual Review of Genetics(IF 17.436), 2018, Vol.52, pp.397-419Annual Reviews
摘要:DNA mutations as a consequence of errors during DNA damage repair, replication, or mitosis are the substrate for evolution. In multicellular organisms, mutations can occur in the germline and also in somatic tissues, where they are associated with cancer and other chronic disease...
作者:Titia de Lange
来源:[J].Annual Review of Genetics(IF 17.436), 2018, Vol.52, pp.223-247Annual Reviews
摘要:For more than a decade, it has been known that mammalian cells use shelterin to protect chromosome ends. Much progress has been made on the mechanism by which shelterin prevents telomeres from inadvertently activating DNA damage signaling and double-strand break (DSB) repair...
作者:Jyoti R. Misra , Kenneth D. Irvine
来源:[J].Annual Review of Genetics(IF 17.436), 2018, Vol.52, pp.65-87Annual Reviews
摘要:Hippo signaling is an evolutionarily conserved network that has a central role in regulating cell proliferation and cell fate to control organ growth and regeneration. It promotes activation of the LATS kinases, which control gene expression by inhibiting the activity of the...

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